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The protein encoded by DUSP5 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping DUSP5 Antibodies (59) and DUSP5 Kits (12) and many more products for this protein.
Showing 6 out of 6 products:
Dusp-5 and Snrk-1 control an (show SNRK Proteins)gioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1
The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein.
Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma (show ARHGEF16 Proteins) and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells.
DUSP1 (show DUSP1 Proteins), DUSP4 (show DUSP4 Proteins), and DUSP5 differentially modulate endothelial MAPK (show MAPK1 Proteins) signaling pathways downstream of Tie-2 (show TEK Proteins) receptors.
DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples.
Studies indicate that dual-specificity MAP kinase (show MAPK1 Proteins) phosphatases (MKPs) DUSP6/MKP-3 (show DUSP6 Proteins) and DUSP5 are localized in the cytoplasm and nuclear compartments.
DUSP5 and DUSP6 (show DUSP6 Proteins) selectively control ERK (show EPHB2 Proteins) pathway activity and proliferation.
the differential up-regulation of MKP3 (show DUSP6 Proteins) by Ets2 (show ETS2 Proteins) and of DUSP5 by c-Jun (show JUN Proteins) may converge in similar functional roles for these MAP kinase (show MAPK1 Proteins) phosphatases in the growth arrest versus proliferation decisions of breast cancer cells
In FD-Fms cells, overexpression of human DUSP5 increased M-CSF-dependent proliferation & decreased differentiation. Overexpression in multipotent EGER-Fms cells increased M-CSF-induced proliferation & caused granulocytic, not macrophage, differentiation.
DUSP5 is a direct target of p53 (show TP53 Proteins).
DUSP5 inactivates ERK2 (show MAPK1 Proteins) and causes both nuclear translocation and sequestration of inactive ERK2 (show MAPK1 Proteins).
DUSP5 phosphatase is regulated at the transcriptional level by the MAPK (show MAPK1 Proteins) pathway and that serum responsive element is involved in the regulation of this early response gene.
results suggest an in vivo role for DUSP5 as a tumor suppressor by modulating the oncogenic potential of activated Ras in the epidermis
After SSH between cDNA libraries from FD-Fms cells stimulated by M-CSF in the presence or the absence of U0126, we isolated DUSP5. DUSP5 expression is induced by M-CSF in various myeloid cells & acts as a specific negative-feedback regulator of ERK1/2.
proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 (show IL2 Proteins) actions, and tolerance
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
dual specificity protein phosphatase 5-like
, dual specificity phosphatase 5
, dual specificity protein phosphatase 5
, VH1-like phosphatase 3
, dual specificity protein phosphatase hVH3
, serine/threonine specific protein phosphatase
, MAP-kinase phosphatase (cpg21)
, MAP-kinase phosphatase CPG21
, candidate plasticity-related gene 21