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anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) Antibodies

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. Additionally we are shipping DYRK1A Kits (6) and DYRK1A Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DYRK1A 1859 Q13627
DYRK1A 13548 Q61214
DYRK1A 25255 Q63470
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Top anti-DYRK1A Antibodies at antibodies-online.com

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DYRK1A Antibody (Center) polyclonal antibody in HL60 cell line lysates (35ug/lane). DYRK1A (arrow) was detected using the purified Pab (1:60 dilution). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DYRK1A Antibody (N-term) in 293 cell line lysates (35ug/lane). DYRK1A (arrow) was detected using the purified Pab (1:60 dilution). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DYRK1A in HeLa cell lysate with DYRK1A antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Dyrk1a Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Mouse Heart WB Suggested Anti-Dyrk1a  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Mouse Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Mouse Dyrk1a Antibody (C-term) (ABIN1881275) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the Mouse Dyrk1a antibody detected the Mouse Dyrk1a protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of DYRK1A Antibody (N-term) (ABIN391798) in 293 cell line lysates (35 µg/lane). DYRK1A (arrow) was detected using the purified polyclonal antibody (1:60 dilution). DYRK1A Antiboty (N-term) (ABIN391798) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in Hela S3 NE. DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in 293 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of DYRK1A Antibody (Center) polyclonal antibody (ABIN391799) in HL60 cell line lysates (35 µg/lane). DYRK1A (arrow) was detected using the purified polyclonal antibody (1:60 dilution). 400 μL Log in to see 10 to 11 Days
$324.50
Details

DYRK1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DYRK1A Antibodies

  1. Human Monoclonal DYRK1A Primary Antibody for ELISA, WB - ABIN560675 : Aranda, Alvarez, Turró, Laguna, de la Luna: Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. in Molecular and cellular biology 2008 (PubMed)
    Show all 38 references for ABIN560675

  2. Human Polyclonal DYRK1A Primary Antibody for WB - ABIN1881275 : Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN1881275

  3. Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN359711 : Adayev, Chen-Hwang, Murakami, Lee, Bolton, Hwang: Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro. in Biochemistry 2007 (PubMed)
    Show all 4 references for ABIN359711

  4. Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN359712 : Chang, Lin, Yang, Yen, Lai, Chen, Liang, Yu: Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis. in International journal of cancer. Journal international du cancer 2007 (PubMed)
    Show all 4 references for ABIN359712

  5. Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN783434 : Park, Oh, Chung: Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. in BMB reports 2009 (PubMed)

More Antibodies against DYRK1A Interaction Partners

Human Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models

  2. Cyclin D1 (show CCND1 Antibodies) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.

  3. data indicate that host factor DYRK1A plays a role in the regulation of viral transcription and latency.

  4. Inhibition of DYRK1A and GSK3B (show GSK3b Antibodies) induces human beta-cell proliferation

  5. A de novo splice site mutation and a de novo nonsense mutation in DYRK1A were identified in two patients with syndromic intellectual disability.

  6. RNA-seq evidence of biallelic expression of DYRK1A and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of DYRK1A is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (show WRB Antibodies) differentially methylated region (DMR (show WDR20 Antibodies)) in disomic controls or trisomy (Down syndrome) individuals.

  7. Our report represents the largest cohort of individuals with DYRK1A disruptions to date, and is the first attempt to define consistent genotype-phenotype correlations among subjects with 21q22.13 microdeletions and DYRK1A SNVs or small INDELs.

  8. We identified unique truncating and non-synonymous mutations (three nonsense, four frameshift and two missense) in DYRK1A in nine patients and a large chromosomal deletion that encompassed DYRK1A in one patient

  9. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.

  10. novel mutations in DYRK1A contribute to the phenotype of the DYRK1A-associated developmental disorder

Mouse (Murine) Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. study identifies DYRK1A-STAT (show STAT1 Antibodies) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome

  2. This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.

  3. Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.

  4. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.

  5. Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.

  6. these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.

  7. Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.

  8. DYRK1A has a role in lymphopoiesis; Cyclin D3 (show CCND3 Antibodies) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development

  9. Dyrk1A has a role in phosphorylation and inactivation of GSK3beta (show GSK3b Antibodies)

  10. Study shows that DYRK1A overexpression affects pathways involved in synaptogenesis and synaptic plasticity and influences excitation/inhibition balance toward inhibition

Xenopus laevis Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Dyrk1A positively and selectively modulates p120-catenin (show CTNND1 Antibodies) protein levels, thus having an impact on p120-catenin (show CTNND1 Antibodies) and Kaiso (show ZBTB33 Antibodies) (and canonical Wnt (show WNT2 Antibodies)) gene targets such as siamois and wnt11.

DYRK1A Antigen Profile

Protein Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Gene names and symbols associated with DYRK1A

  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) antibody
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (dyrk1a) antibody
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a) antibody
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1a) antibody
  • 2310043O08Rik antibody
  • D16Ertd272e antibody
  • D16Ertd493e antibody
  • Dyrk antibody
  • DYRK1 antibody
  • DYRK1A antibody
  • ENSMUSG00000074897 antibody
  • Gm10783 antibody
  • HP86 antibody
  • mmb antibody
  • MNB antibody
  • Mnbh antibody
  • Mp86 antibody
  • MRD7 antibody
  • PSK47 antibody

Protein level used designations for DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A , dual specificity tyrosine-phosphorylation-regulated kinase 1A , minibrain , protein kinase minibrain homolog , dual specificity tyrosine-phosphorylation-regulated kinase 1A-like , MNB/DYRK protein kinase , dual specificity YAK1-related kinase , hMNB , mnb protein kinase homolog hp86 , serine/threonine kinase MNB , serine/threonine-specific protein kinase , Dual Specificity Yak1-related kinase , MNBH , RP86 , minibrain protein kinase , Protein kinase minibrain homolog

GENE ID SPECIES
100051707 Equus caballus
458545 Pan troglodytes
693812 Macaca mulatta
779733 Xenopus (Silurana) tropicalis
100019775 Monodelphis domestica
100078677 Ornithorhynchus anatinus
100389032 Callithrix jacchus
100479774 Ailuropoda melanoleuca
100562279 Anolis carolinensis
100601498 Nomascus leucogenys
1859 Homo sapiens
13548 Mus musculus
25255 Rattus norvegicus
100350296 Oryctolagus cuniculus
395233 Gallus gallus
100514684 Sus scrofa
446302 Xenopus laevis
487755 Canis lupus familiaris
532989 Bos taurus
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