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DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. Additionally we are shipping DYRK1A Kits (6) and DYRK1A Proteins (6) and many more products for this protein.
Showing 10 out of 122 products:
Human Monoclonal DYRK1A Primary Antibody for ELISA, WB - ABIN560675
Aranda, Alvarez, Turró, Laguna, de la Luna: Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. in Molecular and cellular biology 2008
Show all 38 references for ABIN560675
Human Polyclonal DYRK1A Primary Antibody for WB - ABIN1881275
Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. in The Journal of biological chemistry 2010
Show all 4 references for ABIN1881275
Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN359712
Chang, Lin, Yang, Yen, Lai, Chen, Liang, Yu: Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis. in International journal of cancer. Journal international du cancer 2007
Show all 4 references for ABIN359712
Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN359711
Adayev, Chen-Hwang, Murakami, Lee, Bolton, Hwang: Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro. in Biochemistry 2007
Show all 4 references for ABIN359711
Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN783434
Park, Oh, Chung: Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. in BMB reports 2009
mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models
Cyclin D1 (show CCND1 Antibodies) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.
data indicate that host factor DYRK1A plays a role in the regulation of viral transcription and latency.
Inhibition of DYRK1A and GSK3B (show GSK3b Antibodies) induces human beta-cell proliferation
A de novo splice site mutation and a de novo nonsense mutation in DYRK1A were identified in two patients with syndromic intellectual disability.
RNA-seq evidence of biallelic expression of DYRK1A and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of DYRK1A is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (show WRB Antibodies) differentially methylated region (DMR (show WDR20 Antibodies)) in disomic controls or trisomy (Down syndrome) individuals.
Our report represents the largest cohort of individuals with DYRK1A disruptions to date, and is the first attempt to define consistent genotype-phenotype correlations among subjects with 21q22.13 microdeletions and DYRK1A SNVs or small INDELs.
We identified unique truncating and non-synonymous mutations (three nonsense, four frameshift and two missense) in DYRK1A in nine patients and a large chromosomal deletion that encompassed DYRK1A in one patient
the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.
novel mutations in DYRK1A contribute to the phenotype of the DYRK1A-associated developmental disorder
study identifies DYRK1A-STAT (show STAT1 Antibodies) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome
This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.
Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.
Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.
these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.
Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.
DYRK1A has a role in lymphopoiesis; Cyclin D3 (show CCND3 Antibodies) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development
Dyrk1A has a role in phosphorylation and inactivation of GSK3beta (show GSK3b Antibodies)
Study shows that DYRK1A overexpression affects pathways involved in synaptogenesis and synaptic plasticity and influences excitation/inhibition balance toward inhibition
Dyrk1A positively and selectively modulates p120-catenin (show CTNND1 Antibodies) protein levels, thus having an impact on p120-catenin (show CTNND1 Antibodies) and Kaiso (show ZBTB33 Antibodies) (and canonical Wnt (show WNT2 Antibodies)) gene targets such as siamois and wnt11.
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
, dual specificity tyrosine-phosphorylation-regulated kinase 1A
, protein kinase minibrain homolog
, dual specificity tyrosine-phosphorylation-regulated kinase 1A-like
, MNB/DYRK protein kinase
, dual specificity YAK1-related kinase
, mnb protein kinase homolog hp86
, serine/threonine kinase MNB
, serine/threonine-specific protein kinase
, Dual Specificity Yak1-related kinase
, minibrain protein kinase
, Protein kinase minibrain homolog