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The protein encoded by DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. Additionally we are shipping DARC Proteins (8) and DARC Kits (5) and many more products for this protein.
Showing 10 out of 156 products:
Human Polyclonal DARC Primary Antibody for ELISA, FACS - ABIN250822
Zeng, Ou, Yu, Feng, Yin, Li, Shen, Shao: Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes. in Breast cancer research and treatment 2011
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Human Polyclonal DARC Primary Antibody for WB - ABIN1881251
Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: Dengue hemorrhagic fever is associated with polymorphisms in JAK1. in European journal of human genetics : EJHG 2010
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Human Polyclonal DARC Primary Antibody for ELISA, IHC - ABIN4304289
Gardner, Patterson, Ashton, Stone, Middleton: The human Duffy antigen binds selected inflammatory but not homeostatic chemokines. in Biochemical and biophysical research communications 2004
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Human Polyclonal DARC Primary Antibody for IHC, ELISA - ABIN1002190
Chaudhuri, Polyakova, Zbrzezna, Williams, Gulati, Pogo: Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. in Proceedings of the National Academy of Sciences of the United States of America 1993
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Human Polyclonal DARC Primary Antibody for IHC (p), WB - ABIN2479380
Murthy, Saxena: Investigations on sarcolemmal ATPase activities in ventricular tissues of swimming trained & sedentary rats. in Indian journal of experimental biology 1979
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The data suggest that selective exposure of the Duffy binding protein (DBP (show GC Antibodies)) binding site within DARC is key to the preferential binding of DBP (show GC Antibodies) to immature reticulocytes, which is the potential mechanism underlying the preferential infection of a reticulocyte subset by P vivax.
population genetic analysis of DARC shows its association with malaria resistance
We showed that DARC expression is down-regulated in CRC (show CALR Antibodies) and associated with clinical pathological features and MVD (show MVD Antibodies) of CRC (show CALR Antibodies). DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC (show CALR Antibodies).
DARC is required for Staphylococcus aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis.
study demonstrates the association of SNP rs12075 from DARC gene with the levels of serum IL8 (show IL8 Antibodies)
DARC levels are elevated in human keloid fibroblasts and might inhibit the secretion of CCL2 (show CCL2 Antibodies).
Through molecular genotyping we also identified polymorphisms in RhCE (show RHCE Antibodies), Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.
Duffy blood group
Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC (show CACNA1C Antibodies) binding by DBP (show GC Antibodies)-RII.
DARC polymorphisms may influence the naturally acquired inhibitory anti-Duffy binding protein II (show ANXA4 Antibodies) immunity
The DARC/CD234 is expressed on macrophages and stabilizes CD82 (show CD82 Antibodies) on long-term repopulating hematopoietic stem cells, promoting their quiescence.
Ackr1 deficiency appears to be protective in the ApoE (show APOE Antibodies) knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine (show CCL1 Antibodies) expression as well as T-cell subset frequency and inflammatory macrophage content.
Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture.
The data showed a role for erythrocyte DARC as a chemokine (show CCL1 Antibodies) reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier.
DARC is crucial for chemokine (show CCL1 Antibodies)-mediated leukocyte recruitment in vivo.
Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.
Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine (show CCL1 Antibodies) trafficking
role of the Duffy antigen and glycophorin A (show GYPA Antibodies) as receptors for rodent malaria parasite invasion of erythrocytes
DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation
Darc regulates bone mineral density (BMD (show BEST1 Antibodies))negatively by increasing osteoclast formation. Darc is proposed as a candidate gene for chromosome 1 BMD (show BEST1 Antibodies) QTL2.
the 5' flanking region of the DARC gene was isolated and characterized
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.
Duffy blood group, chemokine receptor
, duffy antigen/chemokine receptor
, Duffy antigen/chemokine receptor
, Duffy blood group antigen
, Fy glycoprotein
, atypical chemokine receptor 1
, glycoprotein D
, plasmodium vivax receptor
, Duffy antigen receptor for chemokines
, blood group antigen
, duffy antigen/receptor for chemokine glycoprotein