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Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. Additionally we are shipping Dullard Homolog (Xenopus Laevis) Proteins (7) and many more products for this protein.
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Human Polyclonal DULLARD Primary Antibody for EIA, IHC (p) - ABIN951994
Kim, Gentry, Harris, Wiley, Lawrence, Dixon: A conserved phosphatase cascade that regulates nuclear membrane biogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 4 references for ABIN951994
dullard shows specificity for the peptide corresponding to the insulin (show INS Antibodies)-dependent phosphorylation site (Ser106) of lipin
Dullard participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, a cascade that is conserved from yeast to mammals.
Dullard is involved in suppression of TGF-beta (show TGFB1 Antibodies) signaling during endochondral ossification.
Dullard may play a role in the fine-tuning of WNT (show WNT2 Antibodies) signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 (show DVL2 Antibodies) protein during specification of the germ cell lineage.
Dullard keeps BMP signalling at an appropriate level, which is required for nephron maintenance in the postnatal period.
Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.
, C-terminal domain nuclear envelope phosphatase 1
, dullard homolog
, serine/threonine-protein phosphatase dullard
, CTD nuclear envelope phosphatase 1A
, serine/threonine-protein phosphatase dullard-A