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Dynactin 1 (DCTN1) ELISA Kits

DCTN1 encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Additionally we are shipping Dynactin 1 Antibodies (72) and Dynactin 1 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human DCTN1 DCTN1 1639 Q14203
Anti-Mouse DCTN1 DCTN1 13191 O08788
Anti-Rat DCTN1 DCTN1 29167 P28023
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More ELISA Kits for Dynactin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Dynactin 1 (DCTN1) interaction partners

  1. Arfaptin (show ARFIP1 ELISA Kits) physically associates with Glued and other dynactin complex components in the nervous system of both flies and mice and colocalizes with Glued at the Golgi in motor neurons.

  2. It uncovered an important requirement for Lis1 (show PAFAH1B1 ELISA Kits) in promoting the recruitment of dynein and its accessory complex dynactin to RNA localization complexes.

  3. multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain

  4. dynein-dynactin, abnormal spindle protein (Asp (show ASIP ELISA Kits)), and KLP10A (show KIF24 ELISA Kits) have roles in Drosophila spindle pole organization

  5. We conclude that Lis1 (show PAFAH1B1 ELISA Kits)/dynactin act together to regulate multiple, independent functions in mitotic cells, including spindle formation and cell cycle checkpoint release.

  6. Microtubule binding depends on the N-terminal domain of p150[glued].

  7. Mutants in the Lis1 (show PAFAH1B1 ELISA Kits)/dynactin complex strongly decrease maximum and average spindle velocity, consistent with this motor complex mediating spindle/cortex forces.

  8. Dynein-dynactin plays a role in excluding dendritic Dscam (show DSCAM ELISA Kits) from axons by retrograde transport.

  9. show that this cell polarity regulator interacts with Glued during central synapse formation.

Human Dynactin 1 (DCTN1) interaction partners

  1. Data suggest that cargo concentration at ERES is regulated by p150(glued) to coordinate protein sorting and transport carrier formation with the subsequent long-range transport towards the Golgi complex along microtubules.

  2. Study shows p150glued located at the centrosome in a cell cycle-dependent manner where it is abundant during G1/S phase, located in the minus-end of microtubules during G2/M phase and at the minus-end of microtubules in the mitotic phase.

  3. We find that LRRK1-mediated phosphorylation of CLIP-170 (show CLIP1 ELISA Kits) causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR (show EGFR ELISA Kits)-containing endosomes.

  4. The results describe the mutant dynactin p150Glued mouse model of motor neuron disease and show that genetic background influences phenotype in part through a region of chromosome 17 supporting the presence of genetic modifiers.

  5. Dynactin functions as both a dynamic tether and brake during dynein-driven motility.

  6. HPS6 (show HPS6 ELISA Kits) interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes

  7. Taken together, topographic and functional interactions between dynactin, importin-beta (show KPNB1 ELISA Kits) and RanBP2 (show RANBP2 ELISA Kits) are involved in nuclear translocation of IGF-1R (show IGF1R ELISA Kits).

  8. DCTN1 mutations linked with neurogeneration on Guam.

  9. The results of this study DCTN1 mutations may contribute to disparate neurodegenerative diagnoses, including familial motor neuron disease, parkinsonism, and frontotemporal atrophy.

  10. The data of this study showed evidence of both striatal dopaminergic and widespread cortical/subcortical serotonergic dysfunctions in individuals carrying a mutation in the DCTN1 gene.

Mouse (Murine) Dynactin 1 (DCTN1) interaction partners

  1. a mouse model expressing disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is observed.

  2. These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.

  3. Functional relationships between PIK3C3 (show PIK3C3 ELISA Kits), dynactin, and AnkB (show ANKH ELISA Kits) promote axonal transport of organelles and are required for normal axon length.

  4. The direct binding of the dynactin subunit p150(Glued) to JIP1 (show MAPK8IP1 ELISA Kits) competitively inhibits KHC (show KIF5A ELISA Kits) activation in vitro and disrupts the transport of APP (show APP ELISA Kits) in neurons.

  5. These data unveil a previously unrecognized role for the dynein-dynactin motor complex in osteoclast formation and function.

  6. in addition to its ciliogenic roles, Kif3a (show KIF3A ELISA Kits) recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres.

  7. Overexpression of TBCB leads to the decreased localization of p150 (show ABL1 ELISA Kits) to the microtubule network that might result in a functional modulation of this protein complex.

  8. Melanoregulin interacts with the C-terminal domain of Rab-interacting lysosomal protein (RILP (show RILP ELISA Kits)) and forms a complex with RILP (show RILP ELISA Kits) and p150(Glued) (also known as dynactin subunit 1, DCTN1), a component of the dynein-dynactin motor complex.

  9. It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 (show SUN1 ELISA Kits) and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex.

  10. Dctn1 plays an important role in mouse spermiogenesis, and mainly affects the formation of the tail of spermatozoa.

Dynactin 1 (DCTN1) Antigen Profile

Antigen Summary

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Gene names and symbols associated with Dynactin 1 (DCTN1) ELISA Kits

  • dynactin 1 (DCTN1) antibody
  • Glued (Gl) antibody
  • dynactin 1 (p150, glued homolog, Drosophila) (DCTN1) antibody
  • dynactin 1 (Dctn1) antibody
  • dynactin 1 (dctn1) antibody
  • AL022633 antibody
  • CG9206 antibody
  • Chip150 antibody
  • DAP-150 antibody
  • DCTN1 antibody
  • DKFZp469C1813 antibody
  • Dmel\\CG9206 antibody
  • DP-150 antibody
  • Dynactin-1 antibody
  • DYNA_DROME antibody
  • FCP-D antibody
  • Glu antibody
  • glued antibody
  • P135 antibody
  • p150 antibody
  • p150/glued antibody
  • p150 antibody
  • p150[glued] antibody
  • t1 antibody

Protein level used designations for Dynactin 1 (DCTN1) ELISA Kits

dynactin 1 (p150, glued homolog, Drosophila) , CG9206-PA , Gl-PA , dynactin , dynactin P150 , glued , p150[glued] , p150glued , dynactin 1 , dynactin subunit 1 , dynactin subunit 1-like , 150 kDa dynein-associated polypeptide , DAP-150 , DP-150 , dynactin 1, retrograde axonal transport , p150-glued , dynactin 1 (p150, glued homolog)

100053938 Equus caballus
39536 Drosophila melanogaster
459332 Pan troglodytes
100174308 Pongo abelii
100017556 Monodelphis domestica
100169742 Pongo abelii
100346609 Oryctolagus cuniculus
100475411 Ailuropoda melanoleuca
1639 Homo sapiens
13191 Mus musculus
29167 Rattus norvegicus
483106 Canis lupus familiaris
100519249 Sus scrofa
511045 Bos taurus
426238 Gallus gallus
379696 Xenopus laevis
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