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Dynactin 1 Proteins (DCTN1)

DCTN1 encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Additionally we are shipping Dynactin 1 Antibodies (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCTN1 1639 Q14203
DCTN1 13191 O08788
Rat DCTN1 DCTN1 29167 P28023
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Top Dynactin 1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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DCTN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Dynactin 1 (DCTN1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Dynactin 1 (DCTN1) interaction partners

  1. Arfaptin (show ARFIP1 Proteins) physically associates with Glued and other dynactin complex components in the nervous system of both flies and mice and colocalizes with Glued at the Golgi in motor neurons.

  2. It uncovered an important requirement for Lis1 (show PAFAH1B1 Proteins) in promoting the recruitment of dynein and its accessory complex dynactin to RNA localization complexes.

  3. multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain

  4. dynein-dynactin, abnormal spindle protein (Asp), and KLP10A have roles in Drosophila spindle pole organization

  5. We conclude that Lis1 (show PAFAH1B1 Proteins)/dynactin act together to regulate multiple, independent functions in mitotic cells, including spindle formation and cell cycle checkpoint release.

  6. Microtubule binding depends on the N-terminal domain of p150[glued].

  7. Mutants in the Lis1 (show PAFAH1B1 Proteins)/dynactin complex strongly decrease maximum and average spindle velocity, consistent with this motor complex mediating spindle/cortex forces.

  8. Dynein-dynactin plays a role in excluding dendritic Dscam (show DSCAM Proteins) from axons by retrograde transport.

  9. show that this cell polarity regulator interacts with Glued during central synapse formation.

Human Dynactin 1 (DCTN1) interaction partners

  1. Data suggest that cargo concentration at ERES is regulated by p150(glued) to coordinate protein sorting and transport carrier formation with the subsequent long-range transport towards the Golgi complex along microtubules.

  2. Study shows p150glued located at the centrosome in a cell cycle-dependent manner where it is abundant during G1/S phase, located in the minus-end of microtubules during G2/M phase and at the minus-end of microtubules in the mitotic phase.

  3. We find that LRRK1-mediated phosphorylation of CLIP-170 causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR (show EGFR Proteins)-containing endosomes.

  4. The results describe the mutant dynactin p150Glued mouse model of motor neuron disease and show that genetic background influences phenotype in part through a region of chromosome 17 supporting the presence of genetic modifiers.

  5. Dynactin functions as both a dynamic tether and brake during dynein-driven motility.

  6. HPS6 (show HPS6 Proteins) interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes

  7. Taken together, topographic and functional interactions between dynactin, importin-beta (show KPNB1 Proteins) and RanBP2 are involved in nuclear translocation of IGF-1R (show IGF1R Proteins).

  8. DCTN1 mutations linked with neurogeneration on Guam.

  9. The results of this study DCTN1 mutations may contribute to disparate neurodegenerative diagnoses, including familial motor neuron disease, parkinsonism, and frontotemporal atrophy.

  10. The data of this study showed evidence of both striatal dopaminergic and widespread cortical/subcortical serotonergic dysfunctions in individuals carrying a mutation in the DCTN1 gene.

Mouse (Murine) Dynactin 1 (DCTN1) interaction partners

  1. a mouse model expressing disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is observed.

  2. These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.

  3. Functional relationships between PIK3C3 (show PIK3C3 Proteins), dynactin, and AnkB (show ANKH Proteins) promote axonal transport of organelles and are required for normal axon length.

  4. The direct binding of the dynactin subunit p150(Glued) to JIP1 (show MAPK8IP1 Proteins) competitively inhibits KHC (show KIF5A Proteins) activation in vitro and disrupts the transport of APP (show APP Proteins) in neurons.

  5. These data unveil a previously unrecognized role for the dynein-dynactin motor complex in osteoclast formation and function.

  6. in addition to its ciliogenic roles, Kif3a (show KIF3A Proteins) recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres.

  7. Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex.

  8. Melanoregulin (show MREG Proteins) interacts with the C-terminal domain of Rab-interacting lysosomal protein (RILP (show RILP Proteins)) and forms a complex with RILP (show RILP Proteins) and p150(Glued) (also known as dynactin subunit 1, DCTN1), a component of the dynein-dynactin motor complex.

  9. It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 (show SUN1 Proteins) and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex.

  10. Dctn1 plays an important role in mouse spermiogenesis, and mainly affects the formation of the tail of spermatozoa.

Dynactin 1 (DCTN1) Protein Profile

Protein Summary

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Gene names and symbols associated with Dynactin 1 Proteins (DCTN1)

  • dynactin 1 (DCTN1)
  • Glued (Gl)
  • dynactin 1 (p150, glued homolog, Drosophila) (DCTN1)
  • dynactin 1 (Dctn1)
  • dynactin 1 (dctn1)
  • AL022633 protein
  • CG9206 protein
  • Chip150 protein
  • DAP-150 protein
  • DCTN1 protein
  • DKFZp469C1813 protein
  • Dmel\\CG9206 protein
  • DP-150 protein
  • Dynactin-1 protein
  • DYNA_DROME protein
  • FCP-D protein
  • Glu protein
  • glued protein
  • P135 protein
  • p150 protein
  • p150/glued protein
  • p150 protein
  • p150[glued] protein
  • t1 protein

Protein level used designations for Dynactin 1 Proteins (DCTN1)

dynactin 1 (p150, glued homolog, Drosophila) , CG9206-PA , Gl-PA , dynactin , dynactin P150 , glued , p150[glued] , p150glued , dynactin 1 , dynactin subunit 1 , dynactin subunit 1-like , 150 kDa dynein-associated polypeptide , DAP-150 , DP-150 , dynactin 1, retrograde axonal transport , p150-glued , dynactin 1 (p150, glued homolog)

GENE ID SPECIES
100053938 Equus caballus
39536 Drosophila melanogaster
459332 Pan troglodytes
100174308 Pongo abelii
100017556 Monodelphis domestica
100169742 Pongo abelii
100346609 Oryctolagus cuniculus
100475411 Ailuropoda melanoleuca
1639 Homo sapiens
13191 Mus musculus
29167 Rattus norvegicus
483106 Canis lupus familiaris
100519249 Sus scrofa
511045 Bos taurus
426238 Gallus gallus
379696 Xenopus laevis
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