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DCTN2 encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Additionally we are shipping Dynamitin Proteins (11) and Dynamitin Kits (3) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal Dynamitin Primary Antibody for EIA, IHC (p) - ABIN952005
Jacquot, Maidou-Peindara, Benichou: Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex. in The Journal of biological chemistry 2010
Show all 5 references for ABIN952005
Human Monoclonal Dynamitin Primary Antibody for IF, WB - ABIN393305
Pridgeon, Webber, Sha, Li, Chin: Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. in The FEBS journal 2008
Show all 5 references for ABIN393305
Human Polyclonal Dynamitin Primary Antibody for IF, WB - ABIN523956
Chatin, Colombier, Gamblin, Allouis, Le Bouffant: Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5. in The Biochemical journal 2014
Chicken Polyclonal Dynamitin Primary Antibody for WB - ABIN2787686
Camargo, Collura, Rain, Mizuguchi, Hermjakob, Kerrien, Bonnert, Whiting, Brandon: Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. in Molecular psychiatry 2006
Our results suggest a model whereby endocytic activity recruits Dynein to the oocyte cortex. The motor along with its regulators, Dynactin (show DCTN1 Antibodies) and Lis1 (show PAFAH1B1 Antibodies), functions to ensure efficient endocytic uptake and maturation.
Altered levels of Cep135 (show CEP135 Antibodies) and p50 (show LSP1 Antibodies) by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes.
This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10 (show DNAH10 Antibodies), LRIG3, and MYO1A (show MYO1A Antibodies) has been linked to an inherited neuropathy in humans.
dynamitin is involved in the regulation of Nav1.5 (show SCN5A Antibodies) cell-surface density
the determinants of p50 (show CD40 Antibodies)/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin (show DCTN1 Antibodies) complex
Altered levels of Cep135 (show CEP135 Antibodies) and p50 (show CD40 Antibodies) by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes.
the Sec23p component of the COPII complex directly interacts with the dynactin (show DCTN1 Antibodies) complex through the carboxy-terminal cargo-binding domain of p150(Glued (show DCTN1 Antibodies)).
DCTN2 is required in the earliest stages of peroxisome biogenesis.
study does not support a major role for DCTN2 overexpression in carcinogenesis
Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin (show DCTN1 Antibodies) and assemble into a complex with its close binding partner, p24.
The interaction between ZW10 (show ZW10 Antibodies) and dynamitin showed that the N-terminal region of ZW10 (show ZW10 Antibodies) is the major binding site for dynamitin and, like full-length ZW10 (show ZW10 Antibodies), could move along microtubules to the centrosomal area in a dynein-dynactin (show DCTN1 Antibodies)-dependent manner.
These results indicate that the p50 (show ARHGEF7 Antibodies) component of the dynactin (show DCTN1 Antibodies) complex is essential for the survival of sensory neurons and the maintenance of ganglion cell axons, and functions as a major determinant of apicobasal polarity in retinal radial glia.
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
dynactin 2 (p50)
, dynactin subunit 2
, dynactin subunit 2-B
, p50 dynamitin
, 50 kDa dynein-associated polypeptide
, dynactin complex 50 kDa subunit
, growth cone membrane protein 23-48K
, 50 kD dynein-associated polypeptide
, dynactin complex 50 kD subunit
, dynactin subunit 2-A