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The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Proteins (7) and Dynamin 1-Like Kits (4) and many more products for this protein.
Showing 10 out of 125 products:
Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397
Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011
Show all 14 references for ABIN258397
Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391
Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009
Show all 14 references for ABIN258391
Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347
Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 4 references for ABIN564347
Fruit Fly (Drosophila melanogaster) Polyclonal DNM1L Primary Antibody for EIA, WB - ABIN492938
Madhavapeddi, Ballou, Marsh: Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase. in Biochemistry 2002
Show all 4 references for ABIN492938
Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863
Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012
Show all 2 references for ABIN1724863
Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907
Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012
Show all 2 references for ABIN1724907
Dog (Canine) Monoclonal DNM1L Primary Antibody for IF, WB - ABIN968652
Deyo, Chiao, Tainsky: drp, a novel protein expressed at high cell density but not during growth arrest. in DNA and cell biology 1998
The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.
this study reveals coordinated increase of mitochondrial biogenesis and mitophagy in which Drp1 (show CRMP1 Antibodies) plays a central role regulating breast cancer cell metabolism and survival.
Dynamin-related protein 1 (Dpr1 (show DACT1 Antibodies)) activates mitochondrial-dependent apoptosis and indicate that inhibiting Dpr1 (show DACT1 Antibodies) function can protect against chlorpyrifos-induced cytotoxicity.
Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and that fission factors such as actin filaments target productive oligomerization to fission sites.
Dindings demonstrate for the first time, that Drp1 (show CRMP1 Antibodies) is required for Bax (show BAX Antibodies) mitochondrial translocation, but Drp1 (show CRMP1 Antibodies)-induced mitochondrial fragmentation alone is not sufficient to induce apoptosis in DLBCL cells.
Haploinsufficiency of Drp1 (show CRMP1 Antibodies) abolished mitochondrial autophagy and exacerbated the development of heart failure.
Results indicate that a multiprotein complex including PGAM5 (show PGAM5 Antibodies), Bax (show BAX Antibodies) and Drp1 (show CRMP1 Antibodies) proteins specifically formed during intrinsic apoptosis induction.
DNM1L has a critical role in regulating mitochondrial morphology and function [case report of two siblings]
The results indicate that Drp1 (show CRMP1 Antibodies)-dependent mitochondrial fission through MiD49 (show SMCR7 Antibodies)/MiD51 (show SMCR7L Antibodies) regulates cristae remodeling during intrinsic apoptosis.
liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission
that KIF1Bbeta affects mitochondrial dynamics through calcineurin (show PPP3CA Antibodies)-dependent dephosphorylation of Dynamin-related protein 1 (DRP1), causing mitochondrial fission and apoptosis
Parkin (show PARK2 Antibodies) protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1 (show CRMP1 Antibodies).
knockdown of Mfn2 (show MFN2 Antibodies) in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 (show CRMP1 Antibodies) during chondrogenesis resulted in a loss of differentiation ability
Drp1 (show CRMP1 Antibodies) regulates mitochondrial transport in growing dendrites of Purkinje cells and is required for dendritic arborization.
Mff (show MFF Antibodies) cannot bind to assembly-deficient mutants of Drp1 (show CRMP1 Antibodies), suggesting that Mff (show MFF Antibodies) selectively interacts with higher-order complexes of Drp1 (show CRMP1 Antibodies).
Loss of Drp1 (show CRMP1 Antibodies) compromises the intrinsic bioenergetic function of axonal mitochondria, thus revealing a mechanism by which disrupting mitochondrial dynamics can cause dysfunction of axons.
Drp1 (show CRMP1 Antibodies) is required for functionally active mitochondria, and supplementing with ATP can restore the defects induced by Drp1 (show CRMP1 Antibodies) suppression.
These findings strongly suggest that Drp1 (show CRMP1 Antibodies) plays an important role in determining the fate of cells after irradiation via the regulation of mitochondrial dynamics.
our in vivo observations clarify the role of mitochondrial fission in neurons, demonstrating that Drp1 (show CRMP1 Antibodies) ablation in adult forebrain neurons compromises critical neuronal functions without causing overt neurodegeneration.
enhanced ERK (show EPHB2 Antibodies) signaling in Drp1 (show CRMP1 Antibodies)-knockdown macrophages is implicated in the potentiation of NLRP3 (show NLRP3 Antibodies) inflammasome activation, via mediating mitochondrial localization of NLRP3 (show NLRP3 Antibodies) to facilitate the assembly of NLRP3 (show NLRP3 Antibodies) inflammasome
DRP1 (show CRMP1 Antibodies)-dependent apoptotic mitochondrial fission occurs independently of BAX (show BAX Antibodies), BAK (show BAK1 Antibodies) and APAF1 (show APAF1 Antibodies) to amplify cell death by BID (show BID Antibodies) and oxidative stress.
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
, dynamin-1-like protein
, Dynamin-1-like protein
, dynamin-1-like protein-like
, dynamin related protein 1
, dynamin-like protein
, smooth muscle cell associated protein-3
, smooth muscle cell-associated protein 3
, Dnm1p/Vps1p-like protein
, dynamin family member proline-rich carboxyl-terminal domain less
, dynamin-like protein 4
, dynamin-like protein IV
, dynamin-related protein 1
, C-terminal region
, N-terminal region
, dynamin-like protein 1