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The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Proteins (7) and Dynamin 1-Like Kits (4) and many more products for this protein.
Showing 10 out of 85 products:
Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347
Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 4 references for ABIN564347
Fruit Fly (Drosophila melanogaster) Polyclonal DNM1L Primary Antibody for EIA, WB - ABIN492938
Madhavapeddi, Ballou, Marsh: Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase. in Biochemistry 2002
Show all 4 references for ABIN492938
Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863
Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012
Show all 2 references for ABIN1724863
Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907
Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012
Show all 2 references for ABIN1724907
Dog (Canine) Monoclonal DNM1L Primary Antibody for IF, WB - ABIN968652
Deyo, Chiao, Tainsky: drp, a novel protein expressed at high cell density but not during growth arrest. in DNA and cell biology 1998
The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.
Haploinsufficiency of Drp1 (show CRMP1 Antibodies) abolished mitochondrial autophagy and exacerbated the development of heart failure.
Results indicate that a multiprotein complex including PGAM5, Bax (show BAX Antibodies) and Drp1 (show CRMP1 Antibodies) proteins specifically formed during intrinsic apoptosis induction.
DNM1L has a critical role in regulating mitochondrial morphology and function [case report of two siblings]
The results indicate that Drp1 (show CRMP1 Antibodies)-dependent mitochondrial fission through MiD49 (show SMCR7 Antibodies)/MiD51 (show SMCR7L Antibodies) regulates cristae remodeling during intrinsic apoptosis.
liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission
that KIF1Bbeta affects mitochondrial dynamics through calcineurin (show PPP3CA Antibodies)-dependent dephosphorylation of Dynamin-related protein 1 (DRP1), causing mitochondrial fission and apoptosis
membrane-anchored Mff (show MFF Antibodies) differentially regulates various Drp1 (show CRMP1 Antibodies) isoforms.
Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT signalling in NKT cell activation, and further suggest that RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling.
These findings provide new insights into the role of the Drp1 (show CRMP1 Antibodies)-dependent mitochondrial pathway in the pathology of osteoporosis.
Data indicate that mitochondrial fission proteins Drp1 (show CRMP1 Antibodies) and Fis1 (show FIS1 Antibodies) are overexpressed in oncocytic cell tumors, and that Drp1 (show CRMP1 Antibodies) expression levels correlates with cell tumor malignancy ex vivo and with migration ability.
our in vivo observations clarify the role of mitochondrial fission in neurons, demonstrating that Drp1 (show CRMP1 Antibodies) ablation in adult forebrain neurons compromises critical neuronal functions without causing overt neurodegeneration.
enhanced ERK (show EPHB2 Antibodies) signaling in Drp1 (show CRMP1 Antibodies)-knockdown macrophages is implicated in the potentiation of NLRP3 (show NLRP3 Antibodies) inflammasome activation, via mediating mitochondrial localization of NLRP3 (show NLRP3 Antibodies) to facilitate the assembly of NLRP3 (show NLRP3 Antibodies) inflammasome
DRP1 (show CRMP1 Antibodies)-dependent apoptotic mitochondrial fission occurs independently of BAX (show BAX Antibodies), BAK (show BAK1 Antibodies) and APAF1 (show APAF1 Antibodies) to amplify cell death by BID (show BID Antibodies) and oxidative stress.
These findings provide a mechanism wherein the multimeric states of both Mff (show MFF Antibodies) and Drp1 (show CRMP1 Antibodies) regulate their collaborative interaction.
Results showed that DRP1 (show CRMP1 Antibodies) participated in pulmonary arterial angiogenesis through promoting the migration, stimulating the proliferation, and inhibiting the apoptosis of pulmonary artery endothelial cells via mitochondrial Ca2 (show CA2 Antibodies)+.
DRP1 (show CRMP1 Antibodies) inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.
conditional deletion of CDK5 (show CDK5 Antibodies) significantly attenuates DRP1 (show CRMP1 Antibodies) phosphorylation at S585 and rescues mitochondrial fission defects in neurons exposed to NMDA.
analysis of two types of mitophagy, a DNM1L-dependent pathway and a PARK2 (show PARK2 Antibodies)-dependent pathway
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
, dynamin-1-like protein
, Dynamin-1-like protein
, dynamin-1-like protein-like
, dynamin related protein 1
, dynamin-like protein
, smooth muscle cell associated protein-3
, smooth muscle cell-associated protein 3
, Dnm1p/Vps1p-like protein
, dynamin family member proline-rich carboxyl-terminal domain less
, dynamin-like protein 4
, dynamin-like protein IV
, dynamin-related protein 1
, C-terminal region
, N-terminal region
, dynamin-like protein 1