Dynamin 1-Like Proteins (DNM1L)

The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Antibodies (127) and Dynamin 1-Like Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNM1L 10059 O00429
DNM1L 74006 Q8K1M6
DNM1L 114114 O35303
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Top Dynamin 1-Like Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$860.20
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$4,211.17
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Escherichia coli (E. coli) Fruit Fly Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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DNM1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

Top referenced Dynamin 1-Like Proteins

  1. Human DNM1L Protein expressed in Wheat germ - ABIN1351855 : Qi, Qvit, Su, Mochly-Rosen: A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. in Journal of cell science 2013 (PubMed)
    Show all 4 Pubmed References

  2. Human DNM1L Protein expressed in HEK-293 Cells - ABIN2719860 : Guo, Lu, Huang, Wu, Zhang, Yu, Zhang, Bao, He, Chen, Jia: Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling. in PLoS ONE 2015 (PubMed)

More Proteins for Dynamin 1-Like (DNM1L) Interaction Partners

Human Dynamin 1-Like (DNM1L) interaction partners

  1. The structure and function of DNM1L protein in mitochondrial fission is reviewed.

  2. Results described a recessive disease caused by DNM1L mutations, with a clinical phenotype resembling mitochondrial disorders but without any typical biochemical features. Two novel DNM1L mutations (one frame-shift mutation and one missense mutation) are identified and was found to be associated with impaired mitochondrial and peroxisomal morphology.

  3. Study describes mutations in ZNF143 (show ZNF143 Proteins) causing a previously undescribed inherited disorder of vitamin B12 (show NDUFB3 Proteins) (cobalamin) metabolism. These mutations cause an accumulation of transcobalamin-bound cobalamin within the cells, as well as decreased expression of MMACHC (show MMACHC Proteins), a cobalamin trafficking protein.

  4. The results suggest that endoplasmic reticulum (ER) can function as a platform for Drp1 oligomerization, and that ER-associated Drp1 contributes to mitochondrial division.

  5. PRKAA (show PRKAA2 Proteins) deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L.

  6. hepatic stimulator substance could regulate mitochondrial fission and hepatocyte apoptosis during liver ischemia/reperfusion injury by orchestrating the translocation and activation of Drp1

  7. This report describes a patient with a DNM1L mutation and abnormalities in mitochondrial fission and function. The pathogenicity and the dominant nature of the novel p.G362S mutation are demonstrated by overexpression of the mutant gene.

  8. In contrast to the initial report of neonatal lethality resulting from DNM1L mutation and DRP1 (show CRMP1 Proteins) dysfunction, our results show that milder DRP1 (show CRMP1 Proteins) impairment is compatible with normal early development and subsequently results in a distinct set of neurological findings. In addition, we identify a common pathogenic mechanism whereby DNM1L mutations impair mitochondrial fission.

  9. These findings provide new insights into MCL-1 (show MCL1 Proteins) ligands, and the interplay between DRP-1 (show CRMP1 Proteins) and the anti-apoptotic BCL-2 (show BCL2 Proteins) family members in the regulation of apoptosis

  10. High drp1 expression is associated with cisplatin-induced apoptosis of renal tubular epithelial cells.

Mouse (Murine) Dynamin 1-Like (DNM1L) interaction partners

  1. The structure and function of Dnm1l protein in mitochondrial fission is reviewed.

  2. screening a panel of proteins that regulate mitochondrial morphology in bella GCs (show UGCG Proteins) revealed de-regulation of phospho-Drp1 (show CRMP1 Proteins)(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1 (show OXR1 Proteins), revealing that specific isoforms of this novel antioxidant protein (show PRDX3 Proteins) are associated with mitochondria.

  3. PRKAA (show PRKAA2 Proteins) deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L.

  4. hepatic stimulator substance could regulate mitochondrial fission and hepatocyte apoptosis during liver ischemia/reperfusion injury by orchestrating the translocation and activation of Drp1

  5. Pharmacological inhibition of Drp1 prevents mitochondrial fission and reduces myocardial ischemia-reperfusion injury in diabetic mice.

  6. Report a novel non-canonical function of the fission protein, DRP1 (show CRMP1 Proteins) in maintaining or positively stimulating mitochondrial respiration, bioenergetics and ROS (show ROS1 Proteins) signalling in adult cardiomyocyte, which is likely independent of morphological changes.

  7. Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 and to mitochondrial fragmentation.

  8. Podocyte apoptosis induced by hyperglycemia can be reversed by polydatin through suppressing Drp1 expression.

  9. Heat acclimation and heat shock cause changes in mitochondrial morphology of muscle cells by acting on Drp1, which results in favoring mitochondrial fusion and fission, respectively.

  10. findings provide new insights into the role of the Drp1-dependent mitochondrial pathway in the osteogenic dysfunction during inflammation, indicating that this pathway may be a target for the development of new therapeutic approaches for the prevention and treatment of inflammation-induced bone destruction

Rabbit Dynamin 1-Like (DNM1L) interaction partners

  1. The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Proteins)- and dynamin (show DNM1 Proteins)-dependent pathway.

Fruit Fly (Drosophila melanogaster) Dynamin 1-Like (DNM1L) interaction partners

  1. Data show that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan.

  2. Study showed that exogenous expression of Drp1 could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 is involved in the pathogenesis of Alzheimer disease.

  3. Results show that centronuclear myopathy associated Dyn2 (show DNM2 Proteins) mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 (show DNM2 Proteins) hyperactivity.

  4. Debcl modulates Drp1 mitochondrial localization during apoptosis.

  5. Thus, DRP1-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila

  6. Alterations in both mitochondrial morphology and ATP production caused by either parkin (show PARK2 Proteins) or PINK1 (show PINK1 Proteins) loss of function could be rescued by the mitochondrial fusion proteins Mfn2 (show MFN2 Proteins) and OPA1 (show OPA1 Proteins) or by a dominant negative mutant of the fission protein Drp1.

Dynamin 1-Like (DNM1L) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

Gene names and symbols associated with Dynamin 1-Like Proteins (DNM1L)

  • dynamin 1 like (DNM1L)
  • dynamin 1-like (Dnm1l)
  • dynamin 1-like L homeolog (dnm1l.L)
  • dynamin 1-like (dnm1l)
  • dynamin-1-like (LOC100369408)
  • dynamin 1 like (dnm1l)
  • dynamin-1-like protein (LOC411472)
  • dynamin-like protein (dyn1)
  • dynamin-like protein (cgd1_580)
  • dynamin-like protein (EHI_052740)
  • dynamin-like protein (PVX_092875)
  • dynamin-like protein (BBOV_II002980)
  • dynamin 1 like (Dnm1l)
  • Dynamin related protein 1 (Drp1)
  • 18.m06247 protein
  • 6330417M19Rik protein
  • AI450666 protein
  • CG3210 protein
  • Dlp1 protein
  • Dmel\CG3210 protein
  • Dnm1/Drp1 protein
  • DNM1L protein
  • Dnml1 protein
  • Dnmlp1 protein
  • Drp protein
  • drp-1 protein
  • drp1 protein
  • DVLP protein
  • DYMPLE protein
  • EMPF protein
  • frat protein
  • HDYNIV protein
  • l(2)22Fc protein
  • l(2)22Fd protein
  • l(2)ND2 protein
  • l(2)ND3 protein
  • MGC53850 protein
  • python protein
  • zgc:66163 protein

Protein level used designations for Dynamin 1-Like Proteins (DNM1L)

Dnm1p/Vps1p-like protein , dynamin family member proline-rich carboxyl-terminal domain less , dynamin-1-like protein , dynamin-like protein 4 , dynamin-like protein IV , dynamin-related protein 1 , dymple , C-terminal region , N-terminal region , dynamin-like protein 1 , dynamin 1-like , Dynamin-1-like protein , dynamin-1-like protein-like , dynamin related protein 1 , dynamin-like protein , CG3210 gene product from transcript CG3210-RB , CG3210-PA , CG3210-PB , Drp1-PA , Drp1-PB , dynamin related protein-1 , dynamin-2 , dynamin-related protein , dynaminrelated protein 1 , fratboy , lethal(2)22Fc , lethal(2)22Fd , near dpp complementation group 2 , near dpp complementation group 3 , noodle

GENE ID SPECIES
10059 Homo sapiens
74006 Mus musculus
114114 Rattus norvegicus
379875 Xenopus laevis
393896 Danio rerio
418132 Gallus gallus
465266 Pan troglodytes
477649 Canis lupus familiaris
540892 Bos taurus
695388 Macaca mulatta
100229161 Taeniopygia guttata
100338814 Oryctolagus cuniculus
100369408 Saccoglossus kowalevskii
100380278 Salmo salar
100474116 Ailuropoda melanoleuca
100560647 Anolis carolinensis
411472 Apis mellifera
811008 Plasmodium falciparum 3D7
3371500 Cryptosporidium parvum Iowa II
3405942 Entamoeba histolytica HM-1:IMSS
5474863 Plasmodium vivax Sal-1
5478050 Babesia bovis T2Bo
100728964 Cavia porcellus
33445 Drosophila melanogaster
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