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The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. Additionally we are shipping Dynein, Axonemal, Intermediate Chain 1 Antibodies (44) and many more products for this protein.
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The worldwide involvement of DNAI1 mutations in PCD pathogenesis in families not preselected for ODA defects ranges from 7 to 10%.
A total of 10% of patients with PCD are estimated to harbor mutations in DNAI1; most occur as a common founder IVS1+2_3insT or in exons 13, 16, and 17.
DNAI1 gene mutation is not a common cause of primary ciliary dyskinesia.
Two dynein genes, encoding ODA intermediate chain (DNAI1) and heavy chain (DNAH5), have been seen to be mutated in approximately 30-38% of the families
Dnah6 genetically interacts with Dnai1 and Dnah5 to cause heterotaxy and primary ciliary dyskinesia.
Motile nodal cilia patterns heart looping but heart and visceral organ lateralization is driven by signaling not requiring nodal cilia motility. Dnaic1 mutants can achieve situs solitus or inversus even with immotile nodal cilia.
dnaic1 deletion in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.
dynein, axonemal, intermediate chain 1
, dynein intermediate chain 1, axonemal-like
, dynein intermediate chain 1, axonemal
, dynein, axonemal, intermediate polypeptide 1
, immotile cilia syndrome 1
, axonemal dynein intermediate chain 1