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Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Additionally we are shipping Dynein, Cytoplasmic 1, Light Intermediate Chain 1 Kits (7) and Dynein, Cytoplasmic 1, Light Intermediate Chain 1 Proteins (5) and many more products for this protein.
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although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle.
using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway.
Rab11a (show RAB11A Antibodies), FIP3 (show IKBKG Antibodies) and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 (show IKBKG Antibodies) and Rab11a (show RAB11A Antibodies) in A431 cells.
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity).
, cytoplasmic dynein 1 light intermediate chain 1
, dynein light chain A
, dynein light intermediate chain 1, cytosolic
, dynein, cytoplasmic, light intermediate chain 1
, dynein, cytoplasmic, light intermediate polypeptide 1
, dynein light chain-A
, dyenin light chain A