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The protein encoded by DTNA belongs to the dystrobrevin subfamily of the dystrophin family. Additionally we are shipping DTNA Antibodies (81) and DTNA Proteins (6) and many more products for this protein.
Ordered disorder of the astrocytic dystrophin (show DMD ELISA Kits)-associated protein complex in the norm and pathology.
A phosphorylation site on alpha-dystrobrevin-1 is essential for functional interactions with several proteins at the neuromuscular junction.
Alpha-dystrobrevin is a multifunctional protein that increases dystrophin's binding to the dystrophin (show DMD ELISA Kits)-glycoprotein complex.
Loss of alpha dystrobrevin is associated with perturbation in cell cycle progression and nuclei shape.
alpha-dystrobrevin emerges as a central organizer of dystrophin (show DMD ELISA Kits)-associated protein in glial endfeet and a rare example of a glial protein with a role in maintaining BBB (show ALMS1 ELISA Kits) function
the interaction between alpha-catulin (show CTNNAL1 ELISA Kits) and alpha-dystrobrevin is evolutionarily conserved in C. elegans and mouse muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin (show DMD ELISA Kits) complex
The ErbB2 (show ERBB2 ELISA Kits) signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of alpha-dystrobrevin1.
This is the first demonstration in which assembly of an astroglial protein scaffold containing syntrophin and dystrophin (show DMD ELISA Kits) in perivascular astrocytes is dependent on the presence of alpha-dystrobrevin.
Fundamental functional differences between the alpha-dystrobrevins of mice and humans raises questions about the use of the mouse as a model animal for Duchenne muscular dystrophy (show DMD ELISA Kits).
identified a new dystrobrevin-associated protein, DAMAGE; interacts with the N-terminal region of alpha-dystrobrevin
our findings suggest that novel mutations in FAM136A and DTNA genes are probably causal variants in FMD (show FLNA ELISA Kits).
Results suggest that alpha-dystrobrevin isoforms play a central role in cytoskeleton reorganization via their multiple interactions with actin and actin-associating proteins.
Data show that alpha-dystrobrevin-1 recruits alpha-catulin (show CTNNAL1 ELISA Kits), which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome.
During a cycle of regeneration in tibialis anterior muscle following myonecrosis, alpha-dystrobrevin reaches 50% of the protein level on day 28 by 6.6 days, regenerating more slowly than dystrophin (show DMD ELISA Kits).
alpha-dystrobrevin and its splice isoforms have a role in signal transduction in myeloid cells during induction of granulocytic differentiation and/or at the commitment stage of differentiation or phagocytic cells
Transgenic expression of either isoform of alpha-dystrobrevin prevented muscle fiber degeneration in knockout mice; however, only alphaDB1 corrected defects at neuromuscular and musculotendinous junctions.
patients with deficiency of beta2-syntrophin and alpha-dystrobrevin presented with severe congenital weakness and died in the first year, and patients with deficiency of alpha-DNT had congenital muscular dystrophy with complete external ophthalmoplegia.
findings suggest that a-dystrobrevin specifically is associated with the tight junctions during their reorganization
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
alpha-dystrobrevin isoform 1a-
, alpha-dystrobrevin isoform 1b+
, alpha-dystrobrevin isoform 1c-
, alpha-dystrobrevin isoform 4a-
, dystrobrevin, alpha
, dystrobrevin alpha
, Dystrobrevin alpha
, dystrophin-related protein 3
, dystrobrevin alpha, pseudogene 1