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The protein encoded by DMPK is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Additionally we are shipping DMPK Proteins (8) and DMPK Kits (4) and many more products for this protein.
Showing 10 out of 71 products:
Human Monoclonal DMPK Primary Antibody for IF, WB - ABIN968595
Jin, Shimizu, Balasubramanyam, Epstein: Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells. in Cell motility and the cytoskeleton 2000
Show all 3 references for ABIN968595
Human Polyclonal DMPK Primary Antibody for IHC, WB - ABIN2775281
Ramasamy, Ren, Mench, Regan: Impact of initial biofilm growth on the anode impedance of microbial fuel cells. in Biotechnology and bioengineering 2008
Show all 2 references for ABIN2775281
Human Polyclonal DMPK Primary Antibody for ELISA, WB - ABIN1533843
Fu, Pizzuti, Fenwick, King, Rajnarayan, Dunne, Dubel, Nasser, Ashizawa, de Jong: An unstable triplet repeat in a gene related to myotonic muscular dystrophy. in Science (New York, N.Y.) 1992
Show all 2 references for ABIN1533843
Sense DMPK RNA foci clearly co-localize with MBNL1 (show MBNL1 Antibodies) and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.
miR (show MLXIP Antibodies)-206 and miR (show MLXIP Antibodies)-148a regulate the DMPK transcript and may functionally cooperate.
In conclusion, our data suggest that the frequency of DMPK mutation carriers and the prevalence of DM1 in the Korean population might be higher than those reported in other ethnicities. Supporting
The results show that a DEAD-box helicase, DDX6 (show DDX6 Antibodies), interacts with CUG-expanded DMPK-mRNA in primary fibroblasts from dystrophia myotonica type 1 patients.
The mismatch repair components MSH2 (show MSH2 Antibodies), MSH3 (show MSH3 Antibodies) and MSH6 (show MSH6 Antibodies) were highly expressed in iPSCs compared with fibroblasts, and only occupied the DMPK1 gene harboring longer CTG.CAG triplet repeats
This work may shed light on the alteration of this class of non-coding RNA as an additional molecular mechanisms involved in DM1 pathophysiology.
Together with HK II (show HK2 Antibodies) and Src (show SRC Antibodies), mitochondrial DMPK is part of a multimolecular complex endowed with antioxidant and pro-survival properties.
DMPK alleles in the samples cover four of five DM1 clinical categories: normal (5 to 34 repeats), mild (50 to 100 repeats), classical (101 to 1000 repeats), and congenital (>1000 repeats
The results of this study supported the conclusion that different patterns of CCG interruptions within the CTG array could modulate the DM1 clinical phenotype, variably affecting the mutational dynamics of the variant repeat.
These data demonstrate that the human DM1 locus carrying very large expansions induced a variety of molecular and physiological defects in transgenic mice, reflecting DM1 to a certain extent.
The data of this study demonstrated that DMPK knockout mice present altered beta-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of beta(1)-adrenergic receptors in cardiac plasma membranes.
Cytosolic DMPK participates in remodeling of the actomyosin cytoskeleton in developing skeletal muscle cells.
Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy
a tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis
Dmpk deficiency results in a sodium (Na) channel abnormality comprising frequent, long bursts of Na channel reopenings during sustained depolarization resulting in a plateau of non-inactivating late Na current.
DMPK has a modulatory role in the control of intracellular Ca2 (show CA2 Antibodies)+ concentration in mouse ventricular cardiomyocytes, loss of which contributes to cardiac dysfunction in myotonic dystrophy.
role for DMPK in synaptic plasticity that could be relevant to the cognitive dysfunction associated with myotonic dystrophy
DMPK isoforms have cell-type and location dependent substrate specificities with a role in organellar and cytoarchitectural dynamics
Dmpk mRNA is expressed in a range of adult mouse tissues that including skeletal muscle, heart, smooth muscle, bone, testis, pituitary, brain, eye, skin, thymus,lung,intestinal epithelium, cartilage and liver.
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
dystrophia myotonica-protein kinase
, myotonic dystrophy protein kinase
, myotonin-protein kinase-like
, DM protein kinase
, DM1 protein kinase
, myotonic dystrophy associated protein kinase
, myotonin protein kinase A
, myotonin-protein kinase
, thymopoietin homolog
, dystrophia myotonica kinase, B15