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Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.
Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F (show E2F1 Antibodies)-containing B-Myb (show MYBL2 Antibodies) promoter sites.
E2F4 is part of a transcriptional repressor complex comprising p130 and HDAC1 (show HDAC1 Antibodies) in cardiac myocytes. Relief from E2F4-dependent gene silencing induces the expression of pro-apoptotic genes.
In terminally differentiated cells, common KDM5A (show KDM5A Antibodies) and E2F4 gene targets were bound by the pRB (show PGR Antibodies)-related protein p130, a DREAM complex component.
We report here a new cellular function of p27 (show CDKN1B Antibodies) as a transcriptional regulator in association with p130/E2F4 complexes that could be relevant for tumorigenesis.
Induction of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in mouse mesenchymal stem cells is associated with activation of the p130 and E2f4 and formation of the p130/Gsk3beta (show GSK3b Antibodies)/beta-catenin (show CTNNB1 Antibodies) complex.
E2F4 plays an important role in enabling osteoblast progenitors to exit the cell cycle and subsequently differentiate thereby contributing to the commitment of these cells to the bone lineage.
Our data indicate that E2F4 is required for cardiomyocyte proliferation and suggest a function for E2F4 in mitosis
E2F4 controls cell cycle exit through different mechanisms.
interactions are regulated by G1 cyclin/cyclin (show PCNA Antibodies)-dependent kinase (show CDK1 Antibodies)-coordinated phosphorylation of endogenous pocket proteins
E2F4 has a role in adipogenesis independent of its cell cycle regulatory activity
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-4 binds with high affinity to RBL1 and RBL2. In some instances, can also bind RB protein (By similarity).
, transcription factor E2F4