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E2F Transcription Factor 6 Proteins (E2F6)

E2F6 encodes a member of the E2F transcription factor protein family. Additionally we are shipping E2F6 Antibodies (76) and E2F6 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
E2F6 1876 O75461
E2F6 50496 O54917
Rat E2F6 E2F6 313978  
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Top E2F6 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

E2F6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for E2F Transcription Factor 6 (E2F6) Interaction Partners

Human E2F Transcription Factor 6 (E2F6) interaction partners

  1. miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.

  2. Analysis data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors.

  3. After replication stress, the checkpoint kinase Chk1 (show CHEK1 Proteins) phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F (show E2F1 Proteins)-dependent transcription, which mediates cell survival by preventing DNA damage and cell death

  4. findings indicate an inhibitory role of E2F6 in the regulation of IL-13 (show IL13 Proteins) and allergy

  5. E2F6 may recruit BRG1 (show SMARCA4 Proteins) in transcriptional regulation of genes important for G1/S phase transition of the cell cycle.

  6. data suggest that E2F (show E2F1 Proteins)- and Myc (show MYC Proteins)-responsive genes are coregulated by E2F6 complex in quiescent cells

  7. results suggest that E2F6 represses transcription of the brca1, ctip (show RBBP8 Proteins), art27 (show UXT Proteins), hp1alpha (show CBX5 Proteins), and the rbap48 (show RBBP4 Proteins) genes and depletion of E2F6 resulted in the recruitment of E2F1 (show E2F1 Proteins) to the target promoters

  8. contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins

  9. E2F6 does not contain the domains required for modulation of squamous differentiation

  10. showed that E2F6, DP1 (show PTGDR Proteins), EPC1 (show SERPINF1 Proteins), EZH2 (show EZH2 Proteins), and Sin3B (show SIN3B Proteins) co-elute, suggesting the identification of a novel E2F6 complex that exists in vivo in both normal and transformed human cell lines

Mouse (Murine) E2F Transcription Factor 6 (E2F6) interaction partners

  1. These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response.

  2. E2f6 was similarly bound to the proximal promoter regions both in embryonic stem cells (ESCs (show NR2E3 Proteins)) and epiblast stem cells (EpiSCs)

  3. Data suggest that during development, E2F6 participates in the recruitment of polycomb (show CBX2 Proteins) proteins to specific target promoters.

  4. The 5' untranslated regions of E2F6 and E2F6b are unusually long, and they contain several upstream AUG codons followed by short reading frames. Our results suggest that translation of E2F6b is initiated by internal ribosome entry.

  5. E2F6 is essential for the long-term somatic silencing of certain male-germ-cell-specific genes, but it is dispensable for cell-cycle regulation.

  6. E2F6 silences SMC1beta and STAG3 in somatic cells

  7. This analysis shows that E2f6 and Bmi1 cooperate in the regulation of Hox genes, and consequently axial skeleton development, but not in the repression of the Ink4a-Arf locus.

E2F6 Protein Profile

Protein Summary

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.

Gene names and symbols associated with E2F6

  • E2F transcription factor 6 (LOC100230762)
  • E2F transcription factor 6 (LOC100347358)
  • E2F transcription factor 6 (E2F6)
  • E2F transcription factor 6 (E2f6)
  • AI462434 protein
  • E2F-6 protein
  • E2F6b protein
  • EMA protein

Protein level used designations for E2F6

E2F transcription factor 6 , transcription factor E2F6 , E2F-6 , E2F-binding site-modulating activity protein , transcriptional repressor E2F6

GENE ID SPECIES
100230762 Taeniopygia guttata
100347358 Oryctolagus cuniculus
1876 Homo sapiens
609996 Canis lupus familiaris
514085 Bos taurus
50496 Mus musculus
313978 Rattus norvegicus
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