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E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008].. Additionally we are shipping E2F7 Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal E2F7 Primary Antibody for IHC, WB - ABIN2780153
de Bruin, Maiti, Jakoi, Timmers, Buerki, Leone: Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. in The Journal of biological chemistry 2003
E2F7 overexpression leads to tamoxifen resistance in breast cancer by competing with E2F1 (show E2F1 Antibodies) at miR (show MLXIP Antibodies)-15a/16 promoter.
RacGAP1 (show RACGAP1 Antibodies) Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
Findings indicate that miR (show MLXIP Antibodies)-424 targets the E2F7 transcript and suppresses endometrial cancer cell growth. Knockdown of E2F7 inhibited Ishikawa and HEC (show NDC80 Antibodies)-1B cell growth.
E2F7 directly increases the transcription and activity of the Sphk1 (show SPHK1 Antibodies)/S1P (show MBTPS1 Antibodies) axis resulting in activation of AKT (show AKT1 Antibodies) and subsequent drug resistance.
E2F-7 can co-localize with gammaH2AX (show H2AFX Antibodies) and 53BP1 (show TP53BP1 Antibodies) in DNA damaged cells, bind directly to the recombining DNA, and, importantly, interact and recruit accessory factors, including CtBP (show CTBP2 Antibodies) and HDAC1 (show HDAC1 Antibodies) and 2, to the DSB.
E2F7 recruits the co-repressor C-terminal-binding protein (CtBP (show CTBP2 Antibodies)) and that CtBP2 (show CTBP2 Antibodies) is essential for E2F7 to repress E2F1 (show E2F1 Antibodies) transcription.
Low E2F7 expression is associated with B-chronic lymphocytic leukemia.
MicroRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia (show BCL11A Antibodies) cells.
E2F7-dependent mechanism contributes to p53 (show TP53 Antibodies)-dependent cell cycle arrest in response to DNA damage.
identify a causal role for E2F7 in cellular senescence and uncover a novel link between the RB and p53 (show TP53 Antibodies) pathways.
E2F7, a novel E2F (show E2F1 Antibodies) family member, can block the E2F (show E2F1 Antibodies)-dependent activation of a subset of E2F (show E2F1 Antibodies) target genes as well as mitigate cellular proliferation of mouse embryo fibroblasts
Results identify E2F7 and E2F8 (show E2F8 Antibodies) as a unique repressive arm of the E2F (show E2F1 Antibodies) transcriptional network that is critical for embryonic development.
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003
E2F transcription factor 7
, transcription factor E2F7
, transcription factor E2F7-like