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E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008].. Additionally we are shipping E2F7 Antibodies (56) and many more products for this protein.
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E2F7 might act as an independent prognostic factor of gliomas and might constitute a potential therapeutic target for this disease
E2F7 overexpression leads to tamoxifen resistance in breast cancer by competing with E2F1 (show E2F1 Proteins) at miR (show MLXIP Proteins)-15a/16 promoter.
RacGAP1 (show RACGAP1 Proteins) Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
Findings indicate that miR (show MLXIP Proteins)-424 targets the E2F7 transcript and suppresses endometrial cancer cell growth. Knockdown of E2F7 inhibited Ishikawa and HEC (show NDC80 Proteins)-1B cell growth.
E2F7 directly increases the transcription and activity of the Sphk1 (show SPHK1 Proteins)/S1P (show MBTPS1 Proteins) axis resulting in activation of AKT (show AKT1 Proteins) and subsequent drug resistance.
E2F-7 can co-localize with gammaH2AX (show H2AFX Proteins) and 53BP1 (show TP53BP1 Proteins) in DNA damaged cells, bind directly to the recombining DNA, and, importantly, interact and recruit accessory factors, including CtBP (show CTBP2 Proteins) and HDAC1 (show HDAC1 Proteins) and 2, to the DSB.
E2F7 recruits the co-repressor C-terminal-binding protein (CtBP (show CTBP2 Proteins)) and that CtBP2 (show CTBP2 Proteins) is essential for E2F7 to repress E2F1 (show E2F1 Proteins) transcription.
Low E2F7 expression is associated with B-chronic lymphocytic leukemia.
MicroRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia (show BCL11A Proteins) cells.
E2F7-dependent mechanism contributes to p53 (show TP53 Proteins)-dependent cell cycle arrest in response to DNA damage.
identify a causal role for E2F7 in cellular senescence and uncover a novel link between the RB and p53 (show TP53 Proteins) pathways.
E2F7, a novel E2F (show E2F1 Proteins) family member, can block the E2F (show E2F1 Proteins)-dependent activation of a subset of E2F (show E2F1 Proteins) target genes as well as mitigate cellular proliferation of mouse embryo fibroblasts
Results identify E2F7 and E2F8 (show E2F8 Proteins) as a unique repressive arm of the E2F (show E2F1 Proteins) transcriptional network that is critical for embryonic development.
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003
E2F transcription factor 7
, transcription factor E2F7
, transcription factor E2F7-like