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E2F8 encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. Additionally we are shipping E2F8 Antibodies (44) and many more products for this protein.
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E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development
transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization
E2F8 is overexpressed in Lung Cancer and is required for the growth of LC cells. E2F8 knockdown reduced the expression of UHRF1 (show UHRF1 Proteins). These findings implicate E2F8 as a novel therapeutic target for LC treatment.
The results identify E2F8 as a repressor and E2F1 (show E2F1 Proteins) as an activator of a transcriptional network controlling polyploidization in mammalian cells.
Analyses indicated that E2F8 could bind to regulatory elements of cyclin D1 (show CCND1 Proteins), regulating its transcription and promoting accumulation of S-phase cells. Findings suggest that E2F8 contributes to the oncogenic potential of HCC (show FAM126A Proteins)
The similarities between E2F-7 (show E2F7 Proteins) and E2F-8 define a new subgroup of the E2F (show E2F1 Proteins) family, and further imply that E2F-7 (show E2F7 Proteins) and E2F-8 may act through overlapping mechanisms in mediating cell cycle control.
E2F8 may have an important role in repressing the expression of E2F (show E2F1 Proteins)-target genes in the S-phase of the cell cycle.
E2F7 (show E2F7 Proteins) and E2F8 act upstream of E2F1 (show E2F1 Proteins), and influence the ability of cells to undergo a DNA-damage response.
Rb and E2F8 collaborate to promote DNA replication.
The specificity of E2F8 in mediating Rb function in erythropoiesis suggests a critical and overlapping roles of Rb and E2f8 in maintaining normal erythropoiesis and in preventing hemolysis.
Overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts.
Results identify E2F7 (show E2F7 Proteins) and E2F8 as a unique repressive arm of the E2F (show E2F1 Proteins) transcriptional network that is critical for embryonic development.
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified.
E2F transcription factor 8
, E2F family member 8
, transcription factor E2F8
, transcription factor E2F8-like
, E2f family member 8