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Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation.
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E2F3a and E2F4, but not E2F5, function to induce cell cycle entry, although E2F4 has more modest activity. E2F3a may induce cell death primarily through activation of p73alpha.
E2F5 protein is down-regulated late in embryogenesis
Results indicate that Raf (show RAF1 Antibodies)-arrested myoblasts may serve as a model system for satellite cell cycle studies and that E2F5 and LEK1 (show CENPF Antibodies) translocation to the nucleus is an important first step during entry into quiescence.
This study investigated if the distribution between nucleus and cytoplasm of the transcription factors E2F4 (show E2F4 Antibodies) and E2F5 is mediated by pRb2/p130 (show RBL2 Antibodies) and if the presence of JCV T-antigen may impair this shuttling by sequestering pRb2/p130 (show RBL2 Antibodies).
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction.
transcription factor E2F5