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SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH1 Proteins (9) and SIAH1 Kits (3) and many more products for this protein.
Showing 10 out of 102 products:
Human Polyclonal SIAH1 Primary Antibody for IP, ELISA - ABIN268796
Guigon, Zhao, Lu, Willingham, Cheng: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. in Molecular and cellular biology 2008
Show all 6 references for 268796
Human Polyclonal SIAH1 Primary Antibody for EIA, WB - ABIN954801
Wen, Yang, Song, Li, Yao, Chen, Zhao, Lu, Zhu, Wang: The expression of SIAH1 is downregulated and associated with Bim and apoptosis in human breast cancer tissues and cells. in Molecular carcinogenesis 2010
Show all 3 references for 954801
Human Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN184675
Susini, Passer, Amzallag-Elbaz, Juven-Gershon, Prieur, Privat, Tuynder, Gendron, Israël, Amson, Oren, Telerman: Siah-1 binds and regulates the function of Numb. in Proceedings of the National Academy of Sciences of the United States of America 2001
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Human Polyclonal SIAH1 Primary Antibody for IHC, IHC (p) - ABIN4353439
Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015
Human Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN1533986
Hu, Chung, Glover, Valentine, Look, Fearon: Characterization of human homologs of the Drosophila seven in absentia (sina) gene. in Genomics 1998
Cow (Bovine) Polyclonal SIAH1 Primary Antibody for IHC, WB - ABIN2778297
Avraham, Szargel, Eyal, Rott, Engelender: Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation. in The Journal of biological chemistry 2005
Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt (show WNT2 Antibodies)-induced Axin (show AXIN1 Antibodies) degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 Antibodies) through interacting with a VxP motif in the GSK3 (show GSK3b Antibodies)-binding domain of Axin (show AXIN1 Antibodies), and this function of SIAH is counteracted by GSK3 (show GSK3b Antibodies) binding to Axin (show AXIN1 Antibodies).
results suggest that CacyBP/SIP (show CACYBP Antibodies) is involved in regulation of the Hsp90 chaperone (show HSP90 Antibodies) machinery
PINK1 (show PINK1 Antibodies) disease mutants failed to recruit synphilin-1 (show SNCAIP Antibodies) and did not activate mitophagy, indicating that PINK1 (show PINK1 Antibodies)-synphilin-1 (show SNCAIP Antibodies)-SIAH-1 represents a new parkin (show PARK2 Antibodies)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.
Results suggest that activated STAT3 (show STAT3 Antibodies) regulates active beta-catenin (show CTNNB1 Antibodies) protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin (show CTNNB1 Antibodies) in HEK293T cells.
Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .
SIAH1 is associated with a tumor promoting role in breast cancer.
In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.
Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.
Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.
findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR
two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
E3 ubiquitin-protein ligase Siah1
, E3 ubiquitin-protein ligase SIAH1
, seven in absentia homolog 1
, seven in absentia 1A
, seven in absentia-like protein 1