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Plays an essential role for activation and immortalization of human B-cells.
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Polyclonal EBNA-3A Primary Antibody for - ABIN306583
Sample, Young, Martin, Chatman, Kieff, Rickinson, Kieff: Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. in Journal of virology 1990
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.