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EF-Hand Calcium Binding Domain 4B Proteins (EFCAB4B)

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Additionally we are shipping EF-Hand Calcium Binding Domain 4B Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EFCAB4B 84766 Q9BSW2
EFCAB4B 381812 Q3UP38
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Top EF-Hand Calcium Binding Domain 4B Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EFCAB4B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for EF-Hand Calcium Binding Domain 4B (EFCAB4B) Interaction Partners

Human EF-Hand Calcium Binding Domain 4B (EFCAB4B) interaction partners

  1. endothelial cells contain a long variant of CRACR2A which is an EF-hand-containing Rab (show HRB Proteins) protein that lacks impact on CRAC channels

  2. CRACR2A interacts directly with Orai1 and STIM1 (show STIM1 Proteins), forming a ternary complex that dissociates at elevated Ca(2 (show CA2 Proteins)+) concentrations; is a key regulator of CRAC channel-mediated SOCE

EF-Hand Calcium Binding Domain 4B (EFCAB4B) Protein Profile

Protein Summary

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity).

Gene names and symbols associated with EFCAB4B

  • EF-hand calcium binding domain 4B (EFCAB4B)
  • EF-hand calcium binding domain 4B (Efcab4b)
  • CRACR2A protein
  • Gm462 protein
  • Gm1073 protein

Protein level used designations for EFCAB4B

CRAC channel regulator 2A , EF-hand calcium-binding domain-containing protein 4B , calcium release-activated calcium channel regulator 2A

GENE ID SPECIES
84766 Homo sapiens
381812 Mus musculus
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