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anti-EF-Hand Domain (C-terminal) Containing 1 (EFHC1) Antibodies

EFHC1 encodes an EF-hand-containing calcium binding protein. Additionally we are shipping EFHC1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EFHC1 301295  
EFHC1 114327 Q5JVL4
EFHC1 71877 Q9D9T8
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Top anti-EFHC1 Antibodies at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-EFHC1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged EFHC1 is 0.3 ng/ml as a capture antibody. Western Blot analysis of EFHC1 expression in transfected 293T cell line by EFHC1 monoclonal antibody (M09), clone 4E7.Lane 1: EFHC1 transfected lysate (Predicted MW: 73.9 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

EFHC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against EFHC1 Interaction Partners

Xenopus laevis EF-Hand Domain (C-terminal) Containing 1 (EFHC1) interaction partners

  1. EFHC1 domains are involved in ciliary localization, ciliogenesis, and the regulation of Wnt8a (show WNT8A Antibodies) signaling

Human EF-Hand Domain (C-terminal) Containing 1 (EFHC1) interaction partners

  1. some EFHC1 mutations may be pathogenic only when introduced into specific genetic backgrounds to juvenile myoclonic epilepsy

  2. Myoclonin1/EFHC1 mutation was suggested releated to juvenile myoclonic epilepsy.

  3. Three SNP alleles in BRD2 (show BRD2 Antibodies), Cx-36 (show GJD2 Antibodies), and ME2 (show CELSR1 Antibodies) and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy.

  4. These results show how Myoclonin1/EFHC1 mutations disrupt brain development and potentially produce structural brain abnormalities on which epileptogenesis is established.

  5. we conclude that mutations in the Myoclonin1/EFHC1 gene are an important cause of juvenile myoclonic epilepsy in Mexican patients.

  6. The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 (show CLU Antibodies) channel linked to cell death.

  7. Mutation analyses identified five missense mutations in EFHC1 that cosegregated with epilepsy or EEG polyspike wave in affected members of six unrelated families with JME and did not occur in 382 control individuals

  8. Deletion analyses revealed that the N-terminal region of EFHC1 is crucial for the association with the mitotic spindle and the midbody. Our results suggest that EFHC1 could play an important role during cell division.

  9. We found no evidence that EFHC1 is a major genetic risk factor for JME susceptibility in Dutch patients.

  10. Mutations in the EFHC1 gene may underlie different types of epilepsy syndromes.

Mouse (Murine) EF-Hand Domain (C-terminal) Containing 1 (EFHC1) interaction partners

  1. Efhc1 (-/-) mouse did not show any abnormalities such as disruption of mitotic spindle structure, impaired M-phase progression, and an increase of apoptosis. Further investigations are required to clarify these discrepancies.

  2. The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 (show TRPM2 Antibodies) channel linked to cell death.

  3. In the adult, low mRNA expression was detected in several brain structures such as cortex, striatum, hippocampus and cerebellum. At E16 (show SLC7A5 Antibodies), EFHC1 mRNA was shown to be expressed in all layers of cortex and not only in cells lining ventricles.

  4. Data report the expression profile and distribution of Efhc1 messenger RNA during mouse and rat brain development, and suggest that Efhc1 expression is more important during initial phases of brain development.

  5. Decrease or loss of function of myoclonin1 may be the molecular basis for epilepsies caused by EFHC1 mutations.

  6. Efhc1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.

EFHC1 Antigen Profile

Protein Summary

This gene encodes an EF-hand-containing calcium binding protein. The encoded protein likely plays a role in calcium homeostasis. Mutations in this gene have been associated with susceptibility to juvenile myoclonic epilepsy and juvenile absence epilepsy. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with EFHC1

  • EF-hand domain (C-terminal) containing 1 (Efhc1) antibody
  • EF-hand domain (C-terminal) containing 1 (EFHC1) antibody
  • EF-hand domain (C-terminal) containing 1 (efhc1) antibody
  • EF-hand domain (C-terminal) containing 1 (LOC100222292) antibody
  • 1700029F22Rik antibody
  • dJ304B14.2 antibody
  • MGC63931 antibody
  • MGC84469 antibody
  • MGC89313 antibody
  • mRib72-1 antibody
  • myoclonin1 antibody
  • zgc:63931 antibody

Protein level used designations for EFHC1

EF-hand domain-containing protein 1 , EF-hand domain (C-terminal) containing 1 , EF-hand domain-containing protein 1-like , myoclonin-1

GENE ID SPECIES
301295 Rattus norvegicus
422041 Gallus gallus
474935 Canis lupus familiaris
510124 Bos taurus
100069174 Equus caballus
100152550 Sus scrofa
393942 Danio rerio
444838 Xenopus laevis
462765 Pan troglodytes
493468 Xenopus (Silurana) tropicalis
708517 Macaca mulatta
100016656 Monodelphis domestica
100222292 Taeniopygia guttata
100352671 Oryctolagus cuniculus
100399650 Callithrix jacchus
100443991 Pongo abelii
100482736 Ailuropoda melanoleuca
100557931 Anolis carolinensis
100586187 Nomascus leucogenys
100079150 Ornithorhynchus anatinus
100547670 Meleagris gallopavo
114327 Homo sapiens
71877 Mus musculus
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