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EF-Hand Domain Family, Member D2 Proteins (EFHD2)

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Additionally we are shipping EF-Hand Domain Family, Member D2 Antibodies (39) and EF-Hand Domain Family, Member D2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EFHD2 27984  
EFHD2 79180 Q96C19
EFHD2 298609 Q4FZY0
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Top EF-Hand Domain Family, Member D2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,603.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,612.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EFHD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for EF-Hand Domain Family, Member D2 (EFHD2) Interaction Partners

Mouse (Murine) EF-Hand Domain Family, Member D2 (EFHD2) interaction partners

  1. These results show that EFhd2 is not essential for platelet function in mice indicating that other cytoskeletal adaptors may functionally compensate its loss.

  2. EFhd2 is a neuronal protein that interferes with kinesin-mediated transport.

  3. a role is found for EFhd2 as a negative regulator of germinal center-dependent humoral type 2 immunity, with implications for the generation of IgE.

  4. Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (show CFL1 Proteins) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183

  5. Characterized EFhd2's calcium binding activity. Results showed mutations of a conserved aspartate on either EF-hand motif disrupted calcium binding activity, indicating that these motifs work in pair as a functional calcium binding domain.

  6. EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.

  7. Swip-1 (show WSB1 Proteins) provides a membrane scaffold that is required for the Syk (show SYK Proteins)-, SLP-65 (show BLNK Proteins)-, and PLCgamma2 (show PLCG2 Proteins)-dependent BCR (show BCR Proteins)-induced calcium flux.

  8. study shows that swiprosin-1 may regulate lifespan and BCR (show BCR Proteins) signaling thresholds in immature B cells

  9. The identification of a novel calcium-binding protein (show GUCA1B Proteins) associated with tau protein in terminally ill tauopathy mouse model suggests that this association may play an important physiological and/or pathological role.

  10. These results suggest that swiprosin-1 is a PKC-beta (show PRKCB Proteins) I/eta-inducible gene and it modulates mast cell activation through NF-kappaB (show NFKB1 Proteins)-dependent pathway.

Human EF-Hand Domain Family, Member D2 (EFHD2) interaction partners

  1. The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state.

  2. EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia.

  3. Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity.

  4. Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (show CFL1 Proteins) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183

  5. EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.

  6. the human Shu complex (hSWS1.SWSAP1 (show SWSAP1 Proteins)) has an evolutionarily conserved function in homologous recombination

  7. Its predominant presence in CD8 (show CD8A Proteins) lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes.

  8. These results suggest that swiprosin-1 is a PKC-beta (show PRKCB Proteins) I/eta-inducible gene and it modulates mast cell activation through NF-kappaB (show NFKB1 Proteins)-dependent pathway.

EF-Hand Domain Family, Member D2 (EFHD2) Protein Profile

Protein Summary

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity).

Gene names and symbols associated with EFHD2

  • EF-hand domain family, member D2 (EFHD2)
  • EF-hand domain family, member D2 (efhd2)
  • EF-hand domain family, member D2 (LOC100345208)
  • EF-hand domain-containing protein D2 (efhd2)
  • EF hand domain containing 2 (Efhd2)
  • EF-hand domain family, member D1 (efhd1)
  • EF-hand domain family, member D2 (Efhd2)
  • 2600015J22Rik protein
  • AA408606 protein
  • D4Wsu27e protein
  • EFHD2 protein
  • fj19b07 protein
  • MGC131292 protein
  • si:ch211-281l24.1 protein
  • si:dkey-72l14.9 protein
  • SWS1 protein
  • wu:fb80e07 protein
  • wu:fj19b07 protein

Protein level used designations for EFHD2

EF-hand domain family, member D2 , EF hand domain family, member D2 , EF-hand domain-containing protein D2 , swiprosin 1 , swiprosin-1 , EF hand domain containing 2

GENE ID SPECIES
430669 Gallus gallus
496711 Xenopus (Silurana) tropicalis
694155 Macaca mulatta
735013 Xenopus laevis
747200 Pan troglodytes
100345208 Oryctolagus cuniculus
100380618 Salmo salar
571114 Danio rerio
27984 Mus musculus
335521 Danio rerio
79180 Homo sapiens
298609 Rattus norvegicus
514259 Bos taurus
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