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May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Additionally we are shipping EF-Hand Domain Family, Member D2 Antibodies (42) and EF-Hand Domain Family, Member D2 Kits (6) and many more products for this protein.
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These results show that EFhd2 is not essential for platelet function in mice indicating that other cytoskeletal adaptors may functionally compensate its loss.
EFhd2 is a neuronal protein that interferes with kinesin-mediated transport.
a role is found for EFhd2 as a negative regulator of germinal center-dependent humoral type 2 immunity, with implications for the generation of IgE.
Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (show CFL1 Proteins) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183
Characterized EFhd2's calcium binding activity. Results showed mutations of a conserved aspartate on either EF-hand motif disrupted calcium binding activity, indicating that these motifs work in pair as a functional calcium binding domain.
EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.
Swip-1 (show WSB1 Proteins) provides a membrane scaffold that is required for the Syk (show SYK Proteins)-, SLP-65 (show BLNK Proteins)-, and PLCgamma2 (show PLCG2 Proteins)-dependent BCR (show BCR Proteins)-induced calcium flux.
study shows that swiprosin-1 may regulate lifespan and BCR (show BCR Proteins) signaling thresholds in immature B cells
The identification of a novel calcium-binding protein (show GUCA1B Proteins) associated with tau protein in terminally ill tauopathy mouse model suggests that this association may play an important physiological and/or pathological role.
These results suggest that swiprosin-1 is a PKC-beta (show PRKCB Proteins) I/eta-inducible gene and it modulates mast cell activation through NF-kappaB (show NFKB1 Proteins)-dependent pathway.
The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state.
EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia.
Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity.
the human Shu complex (hSWS1.SWSAP1 (show SWSAP1 Proteins)) has an evolutionarily conserved function in homologous recombination
Its predominant presence in CD8 (show CD8A Proteins) lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes.
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity).
EF-hand domain family, member D2
, EF hand domain family, member D2
, EF-hand domain-containing protein D2
, swiprosin 1
, EF hand domain containing 2