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May act as a transcriptional transactivator (By similarity). Additionally we are shipping ELL Associated Factor 2 Antibodies (27) and ELL Associated Factor 2 Proteins (5) and many more products for this protein.
A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity.
Findings provide the first convincing line of evidence that EAF and Wnt4 (show WNT4 ELISA Kits) form an auto-regulatory negative feedback loop in vivo.
eaf1 and eaf2/u19 act upstream of noncanonical Wnt (show WNT2 ELISA Kits) signaling to mediate convergence and extension movements
analysis showed that EAF2 and EAF1 are required for the recruitment and retention of Ku70 (show XRCC6 ELISA Kits)/Ku80 (show XRCC5 ELISA Kits) to DNA damage sites and play a functional role in nonhomologous end-joining DNA repair. Findings provide evidence for EAF2 as a key factor mediating androgen protection of DNA damage via Ku70 (show XRCC6 ELISA Kits)/Ku80 (show XRCC5 ELISA Kits) in prostate cancer cells.
EAF2 binding does not alter Smad3 (show SMAD3 ELISA Kits) phosphorylation but causes Smad3 (show SMAD3 ELISA Kits) cytoplasmic retention, competes with Smad4 (show SMAD4 ELISA Kits) for binding to Smad3 (show SMAD3 ELISA Kits), and prevents p300 (show EP300 ELISA Kits)-Smad3 (show SMAD3 ELISA Kits) complex formation
Findings suggest that regulation of the AR signaling pathway, cell proliferation, and migration through FOXA1 (show FOXA1 ELISA Kits) represents an important mechanism of EAF2 suppression of prostate carcinogenesis.
Together these findings identify a novel physical and functional interaction between EAF2 and the Rb pathway.
EAF2 bound to and suppressed HIF-1alpha (show HIF1A ELISA Kits).
the role of the EAF2 in response to simvastatin and lovastatin in HCT-116 colon cancer cells
Data suggest that U19/EAF2 regulates t (show THBS1 ELISA Kits)he expression of TSP-1 via blocking p53 repression of the TSP-1 promoter.
U19 is growth inhibitory and tumor suppressive and that the disruption of androgen-dependent growth inhibition via U19 down-regulation is commonly associated with prostate cancer progression.
ELL (show ELL ELISA Kits)-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL (show ELL ELISA Kits).
The results showed that Eaf2 knockout can reduce UV-induced apoptosis in crystalline lenses and mitigate the formation of cataracts.
These results demonstrate that EAF2-mediated apoptosis in GC B (show NPR2 ELISA Kits) cells limits excessive humoral immune responses and is important for maintaining self-tolerance.
these findings together demonstrated synergistic functional interactions and clinical relevance of concurrent EAF2 and Pten downregulation in prostate carcinogenesis.
Mice deficient in EAF2 had an increased recovery rate and a decreased overall response to the effects of androgen deprivation.
cooperation of VHL (show VHL ELISA Kits) and EAF2 may be critical for angiogenic regulation of the liver and prostate, and concurrent loss of these two tumor suppressors may result in a pro-angiogenic phenotype.
Inhibition of 5alpha-reductase during prostatic tumor regrowth enhances the expression of U19/Eaf2, an androgen-regulated tumor suppressor.
Data show that the expression of TSP-1 (show GZMA ELISA Kits) is down-regulated in the prostate and liver of U19/EAF2 knockout mouse.
Expression of Eaf2 is developmentally regulated.
Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia
Transcriptional activation mediated by FESTA/EAF2, a transcription factor that interacts with S-II (show TCEA1 ELISA Kits), was decreased in RNA polymerase II deficient embryonic stem cells.
May act as a transcriptional transactivator (By similarity).
ELL associated factor 2
, ELL-associated factor 2
, testosterone regulated apoptosis inducer and tumor suppressor
, testosterone-regulated apoptosis inducer and tumor suppressor protein
, ehrlich S-II transcriptional activator factor