ELOVL Fatty Acid Elongase 4 Proteins (ELOVL4)

ELOVL4 encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Additionally we are shipping ELOVL4 Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ELOVL4 83603 Q9EQC4
ELOVL4 6785 Q9GZR5
Rat ELOVL4 ELOVL4 315851  
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Top ELOVL4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

ELOVL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for ELOVL Fatty Acid Elongase 4 (ELOVL4) Interaction Partners

Mouse (Murine) ELOVL Fatty Acid Elongase 4 (ELOVL4) interaction partners

  1. Studies indicate that Knock-IN and Knock-OUT strains of ELOVL4 (STGD3) model development has been to unveil the causal connection between the genotype and early-onset progressive cone degeneration in humans.

  2. ELOVL4 enzymatic activity is governed by individual histidines in its active site and the endoplasmic reticulum microenvironment.

  3. To elucidate the role of VLC-PUFAs in photoreceptor terminals, we conditionally deleted Elovl4 in rod and cone photoreceptors of mice and measured inner retina function, synaptic connectivity, and ultrastructure of rod terminals with reduced VLC-PUFAs.

  4. expression and outer segment mislocalization of the disease-linked 5-base-pair deletion mutant ELOVL4 protein alters photoreceptor structure and function

  5. The mosaic deletion of rod-expressed ELOVL4 protein resulted in a 36 % lower amount of very long chain-PUFA in the retinal phosphatidylcholine (show SGMS2 Proteins) (PC) fraction compared to retinas from wild-type mice.

  6. ELOVL4 was strongly expressed within the holocrine meibomian and sebaceous glands but no ELOVL4 was detected within the central meibomian duct.

  7. the presence of the mutant ELOVL4 does not affect the function of wild-type ELOVL4 in the fully developed 8- to 10-week-old retinas.

  8. Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration.

  9. the critical role of Elovl4 for proper rod or cone photoreceptor function

  10. Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice.

Human ELOVL Fatty Acid Elongase 4 (ELOVL4) interaction partners

  1. Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene

  2. In the control group, four different genetic variations were detected in ELOVL4, and five in PRPH2 (show PRPH2 Proteins). STGD (show ABCA4 Proteins) patients of different ethnicities may carry distinct ELOVL4 and PRPH2 (show PRPH2 Proteins) sequence variants. We believe that the genetic variations identified in this study may be related to STGD (show ABCA4 Proteins) etiopathogenesis.

  3. In patients with intrahepatic cholestasis of pregnancy, there was no elevation in ELOVL4 mRNA in maternal circulation compared with controls.

  4. Both ELOVL4- and PROM1-related maculopathies are characterized by progressive photoreceptor atrophy and central vision loss. Using advanced diagnostic imaging, early disease changes and disease progression can be characterized.

  5. different mutations in ELOVL4 can cause variable phenotypic neurological disorders (Review)

  6. Spinocerebellar ataxia was associated with a novel mutation in ELOVL4 in a large family pedigree.

  7. In this review, we summarize our current understanding of the disease-causing mutation and its potential role in STGD3 pathogenesis.

  8. We propose that transgenic expression of ELOVL4 in the liver will result in the biosynthesis of very long chain-PUFA that can be transported to target.

  9. ELOVL4 is identified as the causative gene for erythrokeratodermia variabilis and spinocerebellar ataxia in a French-Canadian family.

  10. A novel homozygous nonsense mutation in ELOVL4 cuases a neuro-ichthyotic disorder with variable expressivity.

ELOVL4 Protein Profile

Protein Summary

This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration.

Gene names and symbols associated with ELOVL4

  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ002114)
  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ003687)
  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ011025)
  • elongation of very long chain fatty acids protein 4 (CpipJ_CPIJ013819)
  • ELOVL fatty acid elongase 4 (ELOVL4)
  • elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 (elovl4)
  • elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 (Elovl4)
  • ELOVL fatty acid elongase 4 (Elovl4)
  • ADMD protein
  • CT118 protein
  • elovl4 protein
  • ISQMR protein
  • MGC122553 protein
  • STGD2 protein
  • STGD3 protein

Protein level used designations for ELOVL4

elongation of very long chain fatty acids protein 4 , elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 , elongation of very long chain fatty acids family member protein 4 , ELOVL fatty acid elongase 4 , 3-keto acyl-CoA synthase Elovl4 , ELOVL FA elongase 4 , very-long-chain 3-oxoacyl-CoA synthase 4 , 3-keto acyl-CoA synthase ELOVL4 , Stargardt disease 3 (autosomal dominant) , cancer/testis antigen 118 , elongation of very long chain fatty acids-like 4 , elongation of very long chain fatty acids 4

GENE ID SPECIES
6032855 Culex quinquefasciatus
6035294 Culex quinquefasciatus
6043662 Culex quinquefasciatus
6046870 Culex quinquefasciatus
421850 Gallus gallus
462842 Pan troglodytes
481894 Canis lupus familiaris
100124726 Xenopus (Silurana) tropicalis
100596130 Nomascus leucogenys
83603 Mus musculus
6785 Homo sapiens
315851 Rattus norvegicus
692070 Macaca mulatta
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