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ER Degradation Enhancer, Mannosidase alpha-Like 1 Proteins (EDEM1)

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. Additionally we are shipping EDEM1 Antibodies (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EDEM1 9695 Q92611
EDEM1 192193 Q925U4
Rat EDEM1 EDEM1 297504  
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Top EDEM1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

EDEM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1) Interaction Partners

Human ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1) interaction partners

  1. EDEM1 colocalizes with the selective autophagy cargo receptors p62/SQSTM1 (show SQSTM1 Proteins), neighbor of BRCA1 gene 1 (NBR1 (show NBR1 Proteins)) and autophagy-linked FYVE (Alfy) protein, and becomes engulfed by autophagic isolation membranes.

  2. Endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation.

  3. miR (show MLXIP Proteins)-581 promotes hepatitis B virus surface antigen expression by targeting Dicer (show DICER1 Proteins) and EDEM1 in HepG2 cells.

  4. EDEM1 associates with lifespan in animal models, although not humans.

  5. analysis of a shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins

  6. Tyrosinase (show TYR Proteins) degradation is prevented when EDEM1 lacks the intrinsically disordered region

  7. we suggest that a nascent glycoprotein can normally dissociate from EDEM1 and be rescued from endoplasmic reticulum associated degradation by reentering calnexin (show CANX Proteins)-refolding cycles

  8. signal sequence cleavage functionally regulated the association of EDEM1-soluble and membrane-integrated isoforms with distinct ERAD machinery and substrates.

  9. EDEM1 protein recognition may be determined by the structure of the endoplasmic reticulum-associated protein degradation substrate in a study of mutant ricin A-chain transport to the cytosol.

  10. mannose trimming enables delivery of a substrate glycoprotein from EDEM1 to late endoplasmic reticulum degredation steps through association with XTP3-B (show ERLEC1 Proteins)

Mouse (Murine) ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1) interaction partners

  1. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3 (show MAP1LC3A Proteins)-I- and EDEM1-containing membranes

  2. Data suggest Edem1/Edem2 (show EDEM2 Proteins) participate in ricin translocation; overexpression of Edem2 (show EDEM2 Proteins), in contrast to Edem1, promotes ricin subunit A transport from endoplasmic reticulum (ER) to cytosol; transport of ricin P250A mutant is Edem1/Edem2 (show EDEM2 Proteins)-independent.

  3. analysis of a shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins

  4. role of the lectins Htm1p/EDEM in the degradation process of CFTR (show CFTR Proteins)

  5. EDEM has a role in maintenance of protein folding efficiency and secretory capacity

  6. EDEM is involved in retrotranslocation of ricin from the ER to the cytosol.

  7. Cells with defective EDEM1 turnover contain unphysiologically high levels of EDEM1, show enhanced ER associated degradation activity and are characterized by impaired capacity to efficiently complete maturation of model glycopolypeptides.

EDEM1 Protein Profile

Protein Summary

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.

Gene names and symbols associated with EDEM1

  • ER degradation enhancer, mannosidase alpha-like 1 (edem1)
  • ER degradation enhancer, mannosidase alpha-like 1 (EDEM1)
  • ER degradation enhancer, mannosidase alpha-like 1 (Edem1)
  • A130059K23Rik protein
  • EDEM protein
  • EDEM1 protein
  • mKIAA0212 protein
  • RGD1563633 protein
  • zgc:55816 protein

Protein level used designations for EDEM1

ER degradation-enhancing alpha-mannosidase-like 1 , ER degradation enhancer, mannosidase alpha-like 1 , ER degradation-enhancing alpha-mannosidase-like 1-like , ER degradation-enhancing alpha-mannosidase-like protein 1 , ER degradation ER degradation enhancer, mannosidase alpha-like 1

GENE ID SPECIES
394164 Danio rerio
395034 Xenopus (Silurana) tropicalis
476547 Canis lupus familiaris
703085 Macaca mulatta
100013430 Monodelphis domestica
100075916 Ornithorhynchus anatinus
100380799 Salmo salar
100388997 Callithrix jacchus
100468417 Ailuropoda melanoleuca
100543065 Meleagris gallopavo
100567845 Anolis carolinensis
100637820 Amphimedon queenslandica
100049149 Xenopus laevis
416110 Gallus gallus
9695 Homo sapiens
511008 Bos taurus
192193 Mus musculus
297504 Rattus norvegicus
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