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In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). Additionally we are shipping EDEM2 Antibodies (34) and EDEM2 Proteins (4) and many more products for this protein.
EDEM2 and OS-9 (show OS9 ELISA Kits) are required for ER-associated degradation of non-glycosylated sonic hedgehog (show SHH ELISA Kits)
Glycoproteins mannose trimming from Man9GlcNAc2 to Man8GlcNAc2 is conducted mainly by EDEM2.
Degrades misfolded alpha1-antitrypsin in the ER.
EDEM2 regulates endoplasmic reticulum-associated glycoprotein degradation
Data suggest Edem1/Edem2 participate in ricin translocation; overexpression of Edem2, in contrast to Edem1, directly promotes ricin subunit A transport from endoplasmic reticulum (ER) to cytosol; this translocation is not dependent on ER translocon.
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005
ER degradation-enhancing alpha-mannosidase-like 2
, ER degradation-enhancing alpha-mannosidase-like protein 2
, ER degradation-enhancing-mannosidase-like protein 2
, ER degradation enhancer, mannosidase alpha-like 2
, ER degradation-enhancing alpha-mannosidase-like 2-like