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Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.. Additionally we are shipping EEA1 Kits (5) and EEA1 Proteins (4) and many more products for this protein.
Showing 10 out of 115 products:
Chicken Monoclonal EEA1 Primary Antibody for IF, IP - ABIN967982
Allan, Moyer, Balch: Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion. in Science (New York, N.Y.) 2000
Show all 5 references for ABIN967982
Human Polyclonal EEA1 Primary Antibody for - ABIN2017597
Hazeki, Kametani, Murakami, Uehara, Ishikawa, Nigorikawa, Takasuga, Sasaki, Seya, Matsumoto, Hazeki: Phosphoinositide 3-kinase? controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. in PLoS ONE 2011
Show all 2 references for ABIN2017597
Human Monoclonal EEA1 Primary Antibody for IF, ELISA - ABIN521883
Pastuszka, Okamoto, Hamm-Alvarez, MacKay: Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. in Advanced functional materials 2014
Chicken Polyclonal EEA1 Primary Antibody for IHC, WB - ABIN2787560
Selak, Paternain, Fritzler, Lerma: Human autoantibodies against early endosome antigen-1 enhance excitatory synaptic transmission. in Neuroscience 2006
Human Monoclonal EEA1 Primary Antibody for ELISA, WB - ABIN521882
Mojallal, Zheng, Hultin, Audebert, van Harn, Johnsson, Lenander, Fritz, Mieth, Corcoran, Lembo, Hallström, Hartman, Mazure, Weide, Grandér, Borg, Uhlén, Holmgren: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. in Nature communications 2014
Human Polyclonal EEA1 Primary Antibody for IP, IHC - ABIN2779263
Fratti, Chua, Deretic: Induction of p38 mitogen-activated protein kinase reduces early endosome autoantigen 1 (EEA1) recruitment to phagosomal membranes. in The Journal of biological chemistry 2003
EEA1 mobility on endosomes is decreased upon stimulation of EGF receptor (show EGFR Antibodies) endocytosis in HeLa cells
Under the regulation of Rab5 (show RAB5A Antibodies), the fused vesicles are targeted to early endosomes and thus deliver the internalized TbetaRI (show TGFBR1 Antibodies) to the caveolin-1 (show CAV1 Antibodies) and EEA1 double-positive early endosomes (caveolin-1 (show CAV1 Antibodies)-positive early endosomes).
In serum-deprivated HeLa cells with low endocytic activity there two types of EEA1-vesicles: the first one carries the both EEA1 and Rab5 (show RAB5A Antibodies) at high levels; the second consists of weakly decorated EEA1-vesicles that can be both Rab5 (show RAB5A Antibodies)-positive and -negative.
Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase (show RACGAP1 Antibodies) Rab31 (show RAB31 Antibodies)-mediated enhancement of ligand-bound EGF receptor (EGFR (show EGFR Antibodies)) endocytic trafficking.
nuclear uptake of Abeta (show APP Antibodies) involves the dynamin (show DNM1 Antibodies)-dependent EEA1 and TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling pathways.
We therefore propose that the N1072K variant of the EEA1 gene is a candidate mutation for susceptibility to diabetes in the Japanese population.
EEA1 interacts with Phafin2 and colocolizes with Phafin2 in endosome membrane.
NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer.
p97 (show EIF4G2 Antibodies) inhibition causes increased EEA1 self-association at the endosome membrane.
The knockdown of STEAP4 (show STEAP4 Antibodies) inhibits insulin (show INS Antibodies)-stimulated glucose transport and GLUT4 (show SLC2A4 Antibodies) translocation via the attenuated phosphorylation of Akt (show AKT1 Antibodies), independent of the effects of EEA1.
In the present study, decreased expression of EEA1 as well as the rearrangement of the actin was observed when Paracoccidioides brasiliensis was internalized in macrophages.
Tec (show NR4A3 Antibodies) vesicles have a membrane proximal location and overlap with the tyrosine kinase (show TYRO3 Antibodies) Lck (show LCK Antibodies), the Tec (show NR4A3 Antibodies) substrate PLC-gamma1 (show PLCG1 Antibodies), and the early endosomal antigen 1 marker EEA1
phosphomimetic mutation of Thr (show TRH Antibodies)-1392 in EEA1 can bypass the requirement for p38alpha (show MAPK14 Antibodies) in mu opioid receptor (show OPRM1 Antibodies) endocytosis
F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1 (show LAMP1 Antibodies)), with peak coassociation frequencies occurring at 30 and 120 min postinoculation, respectively.
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
early endosome antigen 1, 162kD
, novel protein similar to H.sapiens EEA1, early endosome antigen 1 (EEA1)
, early endosome-associated protein
, endosome-associated protein p162
, zinc finger FYVE domain-containing protein 2