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The protein encoded by EGR2 is a transcription factor with three tandem C2H2-type zinc fingers. Additionally we are shipping EGR2 Kits (26) and EGR2 Proteins (12) and many more products for this protein.
Showing 10 out of 121 products:
Human Polyclonal EGR2 Primary Antibody for IHC (p), IHC - ABIN261100
LeBlanc, Ward, Svaren: Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10. in Molecular and cellular biology 2007
Cow (Bovine) Polyclonal EGR2 Primary Antibody for IHC, WB - ABIN2792631
Yoo, Lee: Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor. in The Journal of biological chemistry 2004
Human Polyclonal EGR2 Primary Antibody for ICC, IF - ABIN258617
Hinze, Mayer, Harst, von Kügelgen: Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes. in Journal of molecular and cellular cardiology 2012
Egr2 and Egr3 (show EGR3 Antibodies) have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 and Egr3 (show EGR3 Antibodies) develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 and Egr3 (show EGR3 Antibodies) confer suppressive activity to CD4 (show CD4 Antibodies)(+) T cells and regulate the production of inhibitory cytokines such as IL-10 (show IL10 Antibodies) and TGF-beta1 (show TGFB1 Antibodies).
Analysis of consensus EGR (show EGR1 Antibodies)-binding elements (EBEs) showed that the immediate early response 3 (show IER3 Antibodies) gene (IER3 (show IER3 Antibodies)) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis.
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 Antibodies))early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1 (show RUNX1 Antibodies), NR4A2 (show NR4A2 Antibodies), EGR2, EGR3 (show EGR3 Antibodies) and ID4 (show ID4 Antibodies) may be key genes associated with the pathogenesis of DS.
EGR2 mutation presents as an axonal Charcot-Marie-Tooth phenotype with variable severity.
MicroRNA20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing EGR2 expression.
These results suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of Guillain-Barre syndrome
A recurrent mutation was identified in EGR2 which appears to be associated with the pathogenesis of schizophrenia.
Knock-down of EGR2 with siRNA was demonstrated to have a similar effect as the over-expression of miR (show MLXIP Antibodies)-330-3p in NSCLC cell lines
Dysregulated Egr-2 is observed in some human autoimmune disorders.
EGR2 knockdown inhibited proliferation, clonogenicity and spheroidal growth in vitro and induced regression of Ewing sarcoma xenografts.
Decreased expression of Krox20 in mice causes degeneration of the aortic leaflets and disorganization of the extracellular matrix, causing valvular dysfunction.
Mir106b regulates pro-allergic properties of dendritic cells and Th2 polarisation by targeting Egr-2 in vitro
let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20
The data suggest that Pak2 (show PAK2 Antibodies) controls thymic Natural Killer T-cell development by providing a signal that links Egr2 to induce PLZF (show ZBTB16 Antibodies), in part by regulating signaling lymphocyte activation molecule (show SLAMF1 Antibodies) 6 expression.
demonstrate a novel function of EGR2/3 that is important for Tfh cell development and Tfh cell-mediated B cell immune responses
Egr-2 was upregulated by NF-kappaB (show NFKB1 Antibodies) activation in p50 (show LSP1 Antibodies)+/+ hippocampal slices.
During heart valve development, Krox20-mediated activation of fibrillar Col1a1 (show COL1A1 Antibodies) and Col3a1 (show COL3A1 Antibodies) genes is crucial to avoid postnatal degeneration of the aortic valve leaflets.
EGR2 promotes peripheral naive T-cell differentiation, with delayed T-cell receptor-induced proliferation in naive T cells from Egr2 conditional knockout mice, and decreased production of cytokines in cells subjected to T-helper differentiation.
A direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation.
The results indicated a novel role for Egr2 in repressing adipocyte lineage commitment and promoting early smooth muscle-like cell differentiation.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Data show that Irx7 and Irx1b are required for the proper formation and specification of rhombomeres 1 to 4, and that Irx7 functionally interacts with Meis1.1 (show MEIS1 Antibodies) to activate the expression of anterior hindbrain markers, such as krox20.
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
E3 SUMO-protein ligase EGR2
, KROX-20, Drosophila, homolog (early growth response-2)
, early growth response protein 2
, zinc finger protein Krox-20
, early growth response 2 (Krox-20 homolog, Drosophila)
, early growth response protein 2b
, protein krx-20