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The protein encoded by EGR2 is a transcription factor with three tandem C2H2-type zinc fingers. Additionally we are shipping EGR2 Antibodies (124) and EGR2 Kits (25) and many more products for this protein.
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Low EGR2 expression is associated with hepatocellular carcinoma.
The study suggests that acetylation of EGR2 is regulated independently of nucleosome remodeling and deacetylase.
Egr2-driven cell surface proteins LAG-3 (show LAG3 Proteins) and 4-1BB (show TNFRSF9 Proteins) can identify dysfunctional tumor antigen-specific CD8 (show CD8A Proteins)(+) TIL (show TLR1 Proteins).
Egr2 and Egr3 (show EGR3 Proteins) have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 and Egr3 (show EGR3 Proteins) develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 and Egr3 (show EGR3 Proteins) confer suppressive activity to CD4 (show CD4 Proteins)(+) T cells and regulate the production of inhibitory cytokines such as IL-10 (show IL10 Proteins) and TGF-beta1 (show TGFB1 Proteins).
Analysis of consensus EGR (show EGR1 Proteins)-binding elements (EBEs) showed that the immediate early response 3 (show IER3 Proteins) gene (IER3 (show IER3 Proteins)) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis.
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 Proteins))early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1 (show RUNX1 Proteins), NR4A2 (show NR4A2 Proteins), EGR2, EGR3 (show EGR3 Proteins) and ID4 (show ID4 Proteins) may be key genes associated with the pathogenesis of DS.
EGR2 mutation presents as an axonal Charcot-Marie-Tooth phenotype with variable severity.
MicroRNA20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing EGR2 expression.
These results suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of Guillain-Barre syndrome
A recurrent mutation was identified in EGR2 which appears to be associated with the pathogenesis of schizophrenia.
Prss56 expression was regulated by Egr2 during mouse decidualization.
Egr2 and 3 are upstream regulators of effector CD4 (show CD4 Proteins) and CD8 (show CD8A Proteins) T cells that are essential for optimal responses with limited immunopathology.
Egr2 and 3 are antagonists of T-bet function in effector T cells and are important for the control of inflammatory responses of T cells.
We discovered that Tead1 (show TEAD1 Proteins) and co-activators Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) are required for Pmp22 (show PMP22 Proteins) expression, as well as for the expression of Egr2 Tead1 (show TEAD1 Proteins) directly binds Pmp22 (show PMP22 Proteins) and Egr2 enhancers early in development and Tead1 (show TEAD1 Proteins) binding is induced during myelination, correlating with Pmp22 (show PMP22 Proteins) expression. The data identify Tead1 (show TEAD1 Proteins) as a novel regulator of Pmp22 (show PMP22 Proteins) expression during development in concert with Sox10 (show SOX10 Proteins) and Egr2
endogenous KLF4 (show KLF4 Proteins) and Krox20 are dispensable for adipogenesis in culture and for brown adipose tissue development in mice. In contrast, the master adipogenic transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Proteins)) is essential.
Decreased expression of Krox20 in mice causes degeneration of the aortic leaflets and disorganization of the extracellular matrix, causing valvular dysfunction.
Mir106b regulates pro-allergic properties of dendritic cells and Th2 polarisation by targeting Egr-2 in vitro
let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20
The data suggest that Pak2 (show PAK2 Proteins) controls thymic Natural Killer T-cell development by providing a signal that links Egr2 to induce PLZF (show ZBTB16 Proteins), in part by regulating signaling lymphocyte activation molecule (show SLAMF1 Proteins) 6 expression.
demonstrate a novel function of EGR2/3 that is important for Tfh cell development and Tfh cell-mediated B cell immune responses
A direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Data show that Irx7 and Irx1b are required for the proper formation and specification of rhombomeres 1 to 4, and that Irx7 functionally interacts with Meis1.1 (show MEIS1 Proteins) to activate the expression of anterior hindbrain markers, such as krox20.
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
E3 SUMO-protein ligase EGR2
, KROX-20, Drosophila, homolog (early growth response-2)
, early growth response protein 2
, zinc finger protein Krox-20
, early growth response 2 (Krox-20 homolog, Drosophila)
, early growth response protein 2b
, protein krx-20