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Transcriptional regulator. Additionally we are shipping EGR4 Antibodies (32) and EGR4 Kits (19) and many more products for this protein.
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EGR4 directly transactivates specific variants (V3 and V4) of the PTHrP gene resulting in subsequent transactivation of the RANKL, IL-6 and IL-8 genes via paracrine action of the PTHrP protein.
data suggest a tendency of gender-specific association of EGR2 (show EGR2 Proteins) and EGR4 in schizophrenia.
Data found multiple differences in gene expression between the high and low infertility risk groups, confirming the importance of an intact hypothalamo-pituitary testicular axis and EGR4 in fertility development
Egr4 expression is triggered by trophic factor neurturin (show NRTN Proteins) to upregulate K-Cl cotransporter (show SLC12A4 Proteins) KCC2 (show SLC12A5 Proteins) in immature neurons.
Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons.
Data suggest that Egr4 may regulate spermatogenesis at multiple steps, with roles in the dividing Sertoli cells, peritubular myoid (show MYO1A Proteins) cells, and the meiotic and elongating haploid germ cell populations.
An important role for Egr4 is indicated in the developmental upregulation of potassium-chloride cotransporter (show SLC12A7 Proteins) (KCC2 (show SLC12A5 Proteins)) gene expression.
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
early growth response 4
, early growth response protein 4
, early response protein NGFI-C
, nerve growth factor-induced protein C
, zinc-finger transcription factor NGFI-C (early response gene)