You are viewing an incomplete version of our website. Please click to reload the website as full version.

Echinoderm Microtubule Associated Protein Like 4 Proteins (EML4)

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). Additionally we are shipping EML4 Antibodies (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat EML4 EML4 313861  
EML4 27436 Q9HC35
EML4 78798 Q3UMY5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top EML4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

EML4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Echinoderm Microtubule Associated Protein Like 4 (EML4) Interaction Partners

Human Echinoderm Microtubule Associated Protein Like 4 (EML4) interaction partners

  1. Data show that inhibition of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK)-mediated stem-like properties enhances the anti-tumor effect.

  2. This review describes the biology of EML4 and ALK, explains the main features of EML4-ALK fusion proteins and outline the therapies that target EML4-ALK in cancer. [review]

  3. We further showed that both EML4-ALK and mutant forms of EGFR (show EGFR Proteins) modulate PD-L1 (show CD274 Proteins) expression via common downstream pathways mediated by MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) and by PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins).

  4. EGFR gene mutations and the EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients in China.

  5. In the absence of EML4, NUDC was no longer able to localize to the mitotic spindle, whereas NUDC was dispensable for EML4 localization.

  6. It was revealed that the EML4-ALK fusion gene was observed predominantly in adenocarcinoma, non-smoking and non-small-cell lung cancers (NSCLC) patients, especially those diagnosed in the advanced clinical stage of NSCLC.

  7. Results suggested that chromothripsis may be a mechanism of oncogenic rearrangement of EML4-ALK.

  8. The FISH-based method of detecting EML4-ALK rearrangement in lung cancer may miss a significant number of patients who could benefit from targeted ALK therapy. IHC should be strongly considered, and NGS is recommended in borderline cases.

  9. H1299 NSCLC cells stably expressing EML4-ALK acquire epithelial-mesenchymal transition (EMT (show ITK Proteins)) phenotype, associated with enhanced invasive migration and increased expression of EMT (show ITK Proteins)-inducing transcription factors.

  10. We have determined crystal structures of the coiled-coils from EML2 and EML4, which describe the structural basis of both EML self-association and oncogenic EML4-ALK activation.

EML4 Protein Profile

Protein Summary

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).

Gene names and symbols associated with EML4

  • echinoderm microtubule associated protein like 4 (Eml4)
  • echinoderm microtubule associated protein like 4 (EML4)
  • echinoderm microtubule associated protein like 4 (eml4)
  • 4930443C24Rik protein
  • AI644019 protein
  • C2orf2 protein
  • ELP120 protein
  • EMAP-4 protein
  • EMAPL4 protein
  • EML4 protein
  • MGC89332 protein
  • ROPP120 protein

Protein level used designations for EML4

echinoderm microtubule-associated protein-like 4 , echinoderm microtubule associated protein like 4 , echinoderm microtubule-associated protein-like 4-like , restrictedly overexpressed proliferation-associated protein , ropp 120 , EMAP-4

GENE ID SPECIES
313861 Rattus norvegicus
483048 Canis lupus familiaris
540187 Bos taurus
100515021 Sus scrofa
448764 Xenopus (Silurana) tropicalis
459180 Pan troglodytes
715091 Macaca mulatta
771345 Gallus gallus
100053784 Equus caballus
100453034 Pongo abelii
27436 Homo sapiens
78798 Mus musculus
735022 Xenopus laevis
Selected quality suppliers for EML4 Proteins (EML4)
Did you look for something else?