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May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). Additionally we are shipping EML4 Antibodies (30) and many more products for this protein.
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EML4-ALK-positive lung cancer is often highly progressive.
case report in which the EML4-ALK fusion gene was identified as a second primary lung cancer after surgically resecting EGFR (show EGFR Proteins) mutation-positive adenocarcinoma
79 (69%) were negative for echinoderm microtubule-associated protein like 4 (EML4)-ALK translocation, nine (8%) were positive and 27 (23%) were unevaluable.
Data suggest that platelets are a valuable source for the non-invasive detection of echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangements and for predicting and monitoring outcome to crizotinib.
Data show that inhibition of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK)-mediated stem-like properties enhances the anti-tumor effect.
This review describes the biology of EML4 and ALK, explains the main features of EML4-ALK fusion proteins and outline the therapies that target EML4-ALK in cancer. [review]
We further showed that both EML4-ALK and mutant forms of EGFR (show EGFR Proteins) modulate PD-L1 (show CD274 Proteins) expression via common downstream pathways mediated by MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) and by PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins).
EGFR gene mutations and the EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients in China.
In the absence of EML4, NUDC was no longer able to localize to the mitotic spindle, whereas NUDC was dispensable for EML4 localization.
It was revealed that the EML4-ALK fusion gene was observed predominantly in adenocarcinoma, non-smoking and non-small-cell lung cancers (NSCLC) patients, especially those diagnosed in the advanced clinical stage of NSCLC.
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).
echinoderm microtubule-associated protein-like 4
, echinoderm microtubule associated protein like 4
, echinoderm microtubule-associated protein-like 4-like
, restrictedly overexpressed proliferation-associated protein
, ropp 120