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EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Additionally we are shipping Ectodysplasin A2 Receptor Antibodies (90) and Ectodysplasin A2 Receptor Kits (4) and many more products for this protein.
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Human Ectodysplasin A2 Receptor Protein expressed in Human Cells - ABIN2004837
Yan, Wang, Hymowitz, Schilbach, Lee, Goddard, de Vos, Gao, Dixit: Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. in Science (New York, N.Y.) 2000
Show all 3 references for ABIN2004837
Rat (Rattus) Ectodysplasin A2 Receptor Protein expressed in Human Cells - ABIN2009308
Sinha, Zachariah, Quiñones, Shindo, Chaudhary: Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. in The Journal of biological chemistry 2002
Show all 3 references for ABIN2009308
Mouse (Murine) Ectodysplasin A2 Receptor Protein expressed in Human Cells - ABIN2007764
Prodi, Pirastu, Maninchedda, Sassu, Picciau, Palmas, Mossa, Persico, Adamo, Angius, Pirastu: EDA2R is associated with androgenetic alopecia. in The Journal of investigative dermatology 2008
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XEDAR activates the non-canonical NF-kappaB (show NFKB1 Proteins) pathway.
To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs.
The results suggest that EDA2R confers susceptibility to early onset female pattern hair loss
A crucial role of the EDA-A2 (show EDA Proteins)/ectodysplasin A2 (XEDAR) interaction is revealed in the p53 (show TP53 Proteins)-signaling pathway.
because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R
Results establish a major role of TRAF3 (show TRAF3 Proteins) and -6 in X-linked ectodermal dysplasia receptor (show EDAR Proteins) (XEDAR) signaling and in the process of ectodermal differentiation.
XEDAR belongs to a novel class of death receptors that lack a discernible death domain but are capable of activating apoptosis in a caspase 8- and FADD-dependent fashion
isoforms of EDA (show EDA Proteins)-A5 and A5',activated NF-kappaB (show NFKB1 Proteins) through receptors EDAR (show EDAR Proteins) and XEDAR
The androgen receptor (show AR Proteins) gene and EDA2R are significantly associated with androgenetic alopecia.
androgen receptor (show AR Proteins)/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness
EDA-A2 (show EDA Proteins) transgenic mice exhibited multifocal myodegeneration; this phenotype was not observed in the absence of XEDAR
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.
X-linked ectodysplasin receptor
, tumor necrosis factor receptor superfamily member 27
, ectodysplasin A2 receptor
, EDA-A2 receptor
, X-linked ectodysplasin-A2 receptor
, tumor necrosis factor receptor superfamily member XEDAR
, X linked ectodysplasin receptor
, ectodysplasin A2 isoform receptor