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ENPP1 is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. Additionally we are shipping ENPP1 Proteins (16) and ENPP1 Kits (15) and many more products for this protein.
Showing 10 out of 142 products:
Mouse (Murine) Monoclonal ENPP1 Primary Antibody for FACS - ABIN2658307
Lau, Doucet, Stadel, Huang, Weber, Kominsky: Enpp1: a potential facilitator of breast cancer bone metastasis. in PLoS ONE 2013
Show all 8 references for ABIN2658307
Mouse (Murine) Monoclonal ENPP1 Primary Antibody for FACS, IF - ABIN2664948
Kato, Nishimasu, Okudaira, Mihara, Ishitani, Takagi, Aoki, Nureki: Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. in Proceedings of the National Academy of Sciences of the United States of America 2012
Show all 8 references for ABIN2664948
Mouse (Murine) Monoclonal ENPP1 Primary Antibody for FACS - ABIN2662714
Nam, Liu, Li, Kragor, Hatch: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation. in The Journal of biological chemistry 2011
Show all 8 references for ABIN2662714
Human Polyclonal ENPP1 Primary Antibody for ELISA, IHC - ABIN4308296
Orriss, Utting, Brandao-Burch, Colston, Grubb, Burnstock, Arnett: Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. in Endocrinology 2007
Show all 6 references for ABIN4308296
Human Polyclonal ENPP1 Primary Antibody for WB - ABIN1881296
Ermakov, Rosenbaum, Malkin, Livshits: Family-based study of association between ENPP1 genetic variants and craniofacial morphology. in Annals of human biology 2010
Show all 5 references for ABIN1881296
Human Polyclonal ENPP1 Primary Antibody for IHC, ELISA - ABIN185487
Meyre, Bouatia-Naji, Tounian, Samson, Lecoeur, Vatin, Ghoussaini, Wachter, Hercberg, Charpentier, Patsch, Pattou, Charles, Tounian, Clément, Jouret, Weill, Maddux, Goldfine, Walley, Boutin, Dina et al.: Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. ... in Nature genetics 2005
Show all 3 references for ABIN185487
Human Polyclonal ENPP1 Primary Antibody for EIA, IHC (p) - ABIN374614
Simão, Yadav, Narisawa, Bolean, Pizauro, Hoylaerts, Ciancaglini, Millán: Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics. in The Journal of biological chemistry 2010
Show all 2 references for ABIN374614
enpp1 can exert its function in tissues that are remote from its site of expression.
Results suggest that heterozygous mutations in the SMB domains of ENPP1 are necessary, but not always sufficient in themselves to cause Cole disease.
The K121Q polymorphism of ENPP1 shows no direct correlation with metabolic syndrome in Han Chinese.
Our findings demonstrate that ENPP1, TCF7L2 (show TCF7L2 Antibodies), and FTO (show FTO Antibodies) may predispose to T2DM in the mixed-ancestry population.
In this exploratory analysis, IRS1 (show IRS1 Antibodies), ENNP1 and TRIB3 (show TRIB3 Antibodies), known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Antibodies) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
we found that patients with severe asthma exacerbation had reduced activity of leukocyte ectonucleotidases and reduced expression of E-NPP1 in PMNs.
A rare type of idiopathic infantile arterial calcification resulting from a mutation in the gene encoding for the ENPP1 enzyme.
Loss of function mutation in ENPP1 is associated with early onset hearing loss in autosomal recessive hypophosphatemic rickets.
ENPP1 was also identified as a substrate of the 26S proteasome (show Psmd4 Antibodies), the activity of which is downregulated in CSCs
Expression of NPP1 and 5'-nucleotidase (show NT5E Antibodies) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (show ADORA2A Antibodies) and a cAMP/PKA/CREB (show CREB1 Antibodies) pathway.
ENPP1 rs1805101 polymorphism is associated with Insulin (show INS Antibodies) resistance and advanced Diabetic nephropathy.
Vitamin D3 regulates Enpp1 expression, which presumably, in the context of adequate tissue non-specific alkaline phosphatase activity, provides phosphate to stimulate mineralisation.
ENPP1-Fc fusion protein prevents the mortality, vascular calcifications and sequela of disease in mouse models of generalized arterial calcification of infancy.
Expression of NPP1 and 5'-nucleotidase (show ACPP Antibodies) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (show ADORA2A Antibodies) and a cAMP/PKA/CREB (show CREB1 Antibodies) pathway.
Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.
NPP1 has a role in obesity and diabetes in a mouse model
we have characterized the phenotypic and histopathologic features of this spontaneous mutant mouse, designated as asj (show ARSJ Antibodies)-2J, and we have identified a large deletion/insertion mutation in the Enpp1 gene
these data highlight the key role of NPP1 in regulating calcification of both soft and skeletal tissues.
ENPP1 2'3'-cGAMP-hydrolyzing activity is repsonsible for tumor progression in humans and mice.
Both mono-allelic and bi-allelic ENPP1 deficiency promote dysregulated VSMC function, with robust C/EBP homologous protein (show DDIT3 Antibodies) expression and enhanced neointimal hyperplasia after injury in vivo, but marked post-injury calcification limited to Enpp1-/- mice.
Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6 (show ABCC6 Antibodies)(tm1Jfk) and Enpp1(asj (show ARSJ Antibodies)) mice.
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
ectonucleotide pyrophosphatase/phosphodiesterase 1
, ectonucleotide pyrophosphatase/phosphodiesterase family member 1
, ectonucleotidase enpp1
, E-NPP 1
, Ly-41 antigen
, alkaline phosphodiesterase 1
, membrane component chromosome 6 surface marker 1
, membrane component, chromosome 6, surface marker 1
, phosphodiesterase I/nucleotide pyrophosphatase 1
, plasma-cell membrane glycoprotein 1
, plasma-cell membrane glycoprotein PC-1
, 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, lymphocyte antigen 41
, phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, tiptoe walking