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The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Additionally we are shipping ENPP2 Kits (17) and ENPP2 Proteins (13) and many more products for this protein.
Showing 10 out of 115 products:
Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN358034
Kawagoe, Soma, Goji, Nishimura, Narita, Inazawa, Nakamura, Sano: Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2). in Genomics 1996
Show all 3 references for ABIN358034
Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN453640
Nam, Clair, Kim, McMarlin, Schiffmann, Liotta, Stracke: Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. in Cancer research 2001
Show all 3 references for ABIN453640
Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN265084
Murata, Lee, Clair, Krutzsch, Arestad, Sobel, Liotta, Stracke: cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. in The Journal of biological chemistry 1994
Show all 2 references for ABIN265084
Mouse (Murine) Polyclonal ENPP2 Primary Antibody for ELISA - ABIN2001293
Boucher, Quilliot, Pradères, Simon, Grès, Guigné, Prévot, Ferry, Boutin, Carpéné, Valet, Saulnier-Blache: Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. in Diabetologia 2005
Show all 2 references for ABIN2001293
Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.
Plasma ATX activity is strongly associated with pruritus in primary biliary cholangitis, authors review the biochemistry of ATX and the rationale for its role in pruritus. [Review]
Data suggest serum ATX levels correlate with presence/intensity of pruritus in pediatric cholestatic disorders; despite therapy, ATX is up-regulated in children with severe pruritus due to cholestatic disorders (AGS (show JAG1 Antibodies), Alagille syndrome; BA, biliary atresia; progressive familial intrahepatic cholestasis) compared to children with cholestatic disorders without pruritus (BASD, bile acid synthesis defects). [PILOT PROJECT]
These findings support our previous work showing reduced ATX antigen levels in the peripheral blood of pre-eclamptic women. A disturbance in placental ATX production may be linked to poor placental development and systemic maternal symptoms in early-onset pre-eclampsia.
These results suggest that autotaxin-LPA-LPA receptor 1-AKT1 signaling axis is critical for maintaining Cancer stem cells(CSC) characteristics through an autocrine loop and provide a novel therapeutic target for ovarian CSCs.
autotaxin (ATX), is an ecto (show TRIM33 Antibodies)-lysophospholipase (show PLA2G4A Antibodies) D encoded by the human ENNP2 gene
Altered expression of ENPP2 is associated with various diseases, such as, inflammation, cancer, fibrosis, rheumatoid arthritis and neural tube defects. (Review)
Serum ATX correlates with and predicts measures of glucose homeostasis and insulin (show INS Antibodies) sensitivity in older humans, suggesting that it may be a potential pathogenic factor and/or diagnostic/therapeutic target for insulin (show INS Antibodies) resistance in this population
ATX was induced in monocytic THP-1 (show GLI2 Antibodies) cells by TLR4 (show TLR4 Antibodies) ligand lipopolysaccharide (LPS (show IRF6 Antibodies)), TLR9 (show TLR9 Antibodies) ligand CpG oligonucleotide, and TLR3 (show TLR3 Antibodies) ligand poly(I:C), respectively
Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer
The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production
inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.
findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation
These findings identify ATX and LPA2 (show LPAR2 Antibodies) as radiation-regulated genes that appear to play a physiological role in DNA repair.
blocking tumor-driven inflammation by ATX inhibition is effective in decreasing tumor growth in breast cancers where the cancer cells express negligible ATX.
ATX expression and lysophosphatidic acid production are significantly enhanced in LPS (show TLR4 Antibodies) treated BV-2 cells.
Enpp2(+/-) mice and adipocyte-specific Enpp2 knockout mice fed a high-fat diet showed smaller weight gains and less insulin (show INS Antibodies) resistance than control mice, as well as more functionally active brown adipose tissue and increased energy expenditure.
high levels of c-Jun (show JUN Antibodies) enhance motility in part by driving the expression of ENPP2/Autotaxin
Autotaxin generates lysophosphatidic acid from lysophophatidylcholine. The role of this pathway in T-lymphocyte homing, inflammation, and airway remodeling is studied and inhibitors are tested. Review.
ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.
These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
, ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
, ectonucleotide pyrophosphatase/phosphodiesterase 2
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2
, E-NPP 2
, extracellular lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2
, plasma lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)