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Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) ELISA Kits

The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Additionally we are shipping ENPP2 Antibodies (109) and ENPP2 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ENPP2 5168 Q13822
ENPP2 18606 Q9R1E6
ENPP2 84050 Q64610
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Top ENPP2 ELISA Kits at antibodies-online.com

Showing 4 out of 16 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 42.16 pg/mL 93.75-6000 pg/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details
Rat 0.97 ng/ml 3.9-250 ng/mL   96 Tests Log in to see 11 to 13 Days
$910.56
Details
Mouse 35.71 ng/ml 71.43-2500 ng/mL   96 Tests Log in to see 11 to 13 Days
$910.56
Details
Cow
  96 Tests Log in to see 11 to 13 Days
$1,029.60
Details

More ELISA Kits for ENPP2 Interaction Partners

Xenopus laevis Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. autotaxin (ATX), is an ecto (show TRIM33 ELISA Kits)-lysophospholipase (show PLA2G4A ELISA Kits) D encoded by the human ENNP2 gene

  2. Altered expression of ENPP2 is associated with various diseases, such as, inflammation, cancer, fibrosis, rheumatoid arthritis and neural tube defects. (Review)

  3. Serum ATX correlates with and predicts measures of glucose homeostasis and insulin (show INS ELISA Kits) sensitivity in older humans, suggesting that it may be a potential pathogenic factor and/or diagnostic/therapeutic target for insulin (show INS ELISA Kits) resistance in this population

  4. ATX was induced in monocytic THP-1 (show GLI2 ELISA Kits) cells by TLR4 (show TLR4 ELISA Kits) ligand lipopolysaccharide (LPS (show IRF6 ELISA Kits)), TLR9 (show TLR9 ELISA Kits) ligand CpG oligonucleotide, and TLR3 (show TLR3 ELISA Kits) ligand poly(I:C), respectively

  5. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  6. The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production

  7. Increased serum autotaxin activity represents a highly sensitive, specific and robust diagnostic marker of Intrahepatic cholestasis of pregnancy , distinguishing ICP from other pruritic disorders of pregnancy and pregnancy-related liver diseases.

  8. blocking tumor-driven inflammation by ATX inhibition is effective in decreasing tumor growth in breast cancers where the cancer cells express negligible ATX.

  9. Autotaxin is transported in the aortic valve by lipoprotein(a) and is also secreted by valve interstitial cells.

  10. Data suggest a role for the autotaxin-lysophosphatidic acid axis in toluene diisocyanate toxicity.

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.

  2. findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation

  3. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  4. These findings identify ATX and LPA2 (show LPAR2 ELISA Kits) as radiation-regulated genes that appear to play a physiological role in DNA repair.

  5. The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production

  6. blocking tumor-driven inflammation by ATX inhibition is effective in decreasing tumor growth in breast cancers where the cancer cells express negligible ATX.

  7. ATX expression and lysophosphatidic acid production are significantly enhanced in LPS (show TLR4 ELISA Kits) treated BV-2 cells.

  8. Enpp2(+/-) mice and adipocyte-specific Enpp2 knockout mice fed a high-fat diet showed smaller weight gains and less insulin (show INS ELISA Kits) resistance than control mice, as well as more functionally active brown adipose tissue and increased energy expenditure.

  9. high levels of c-Jun (show JUN ELISA Kits) enhance motility in part by driving the expression of ENPP2/Autotaxin

  10. Autotaxin generates lysophosphatidic acid from lysophophatidylcholine. The role of this pathway in T-lymphocyte homing, inflammation, and airway remodeling is studied and inhibitors are tested. Review.

Pig (Porcine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.

Cow (Bovine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.

ENPP2 Antigen Profile

Antigen Summary

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ENPP2

  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) antibody
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (enpp2) antibody
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2) antibody
  • ATX antibody
  • ATX-X antibody
  • AUTOTAXIN antibody
  • LysoPLD antibody
  • MGC132047 antibody
  • NPP2 antibody
  • Npps2 antibody
  • PD-Ialpha antibody
  • Pdnp2 antibody
  • zgc:63550 antibody

Protein level used designations for ENPP2

autotaxin , ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 , E-NPP 2 , autotaxin-t , extracellular lysophospholipase D , phosphodiesterase I/nucleotide pyrophosphatase 2 , plasma lysophospholipase D , lysoPLD , phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin) , atx

GENE ID SPECIES
100057101 Equus caballus
464353 Pan troglodytes
548690 Xenopus (Silurana) tropicalis
705287 Macaca mulatta
735240 Xenopus laevis
100173553 Pongo abelii
100219257 Taeniopygia guttata
5168 Homo sapiens
18606 Mus musculus
84050 Rattus norvegicus
393575 Danio rerio
420361 Gallus gallus
482026 Canis lupus familiaris
503658 Sus scrofa
532663 Bos taurus
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