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Ectonucleotide Pyrophosphatase/phosphodiesterase 2 Proteins (ENPP2)

The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Additionally we are shipping ENPP2 Antibodies (109) and ENPP2 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ENPP2 5168 Q13822
ENPP2 18606 Q9R1E6
ENPP2 84050 Q64610
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Top ENPP2 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Cynomolgus His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$915.20
Details
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
$584.38
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 2 to 3 Days
$210.00
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$3,256.00
Details

ENPP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced ENPP2 Proteins

  1. Human ENPP2 Protein expressed in Human Cells - ABIN2004207 : Boucher, Quilliot, Pradères, Simon, Grès, Guigné, Prévot, Ferry, Boutin, Carpéné, Valet, Saulnier-Blache: Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. in Diabetologia 2005 (PubMed)
    Show all 2 references for ABIN2004207

More Proteins for Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaction Partners

Xenopus laevis Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. autotaxin (ATX), is an ecto (show TRIM33 Proteins)-lysophospholipase (show PLA2G4A Proteins) D encoded by the human ENNP2 gene

  2. Altered expression of ENPP2 is associated with various diseases, such as, inflammation, cancer, fibrosis, rheumatoid arthritis and neural tube defects. (Review)

  3. Serum ATX correlates with and predicts measures of glucose homeostasis and insulin (show INS Proteins) sensitivity in older humans, suggesting that it may be a potential pathogenic factor and/or diagnostic/therapeutic target for insulin (show INS Proteins) resistance in this population

  4. ATX was induced in monocytic THP-1 cells by TLR4 (show TLR4 Proteins) ligand lipopolysaccharide (LPS (show IRF6 Proteins)), TLR9 (show TLR9 Proteins) ligand CpG oligonucleotide, and TLR3 (show TLR3 Proteins) ligand poly(I:C), respectively

  5. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  6. The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production

  7. Increased serum autotaxin activity represents a highly sensitive, specific and robust diagnostic marker of Intrahepatic cholestasis of pregnancy , distinguishing ICP from other pruritic disorders of pregnancy and pregnancy-related liver diseases.

  8. blocking tumor-driven inflammation by ATX inhibition is effective in decreasing tumor growth in breast cancers where the cancer cells express negligible ATX.

  9. Autotaxin is transported in the aortic valve by lipoprotein(a) and is also secreted by valve interstitial cells.

  10. Data suggest a role for the autotaxin-lysophosphatidic acid axis in toluene diisocyanate toxicity.

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.

  2. findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation

  3. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  4. These findings identify ATX and LPA2 (show LPAR2 Proteins) as radiation-regulated genes that appear to play a physiological role in DNA repair.

  5. The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production

  6. blocking tumor-driven inflammation by ATX inhibition is effective in decreasing tumor growth in breast cancers where the cancer cells express negligible ATX.

  7. ATX expression and lysophosphatidic acid production are significantly enhanced in LPS (show TLR4 Proteins) treated BV-2 cells.

  8. Enpp2(+/-) mice and adipocyte-specific Enpp2 knockout mice fed a high-fat diet showed smaller weight gains and less insulin (show INS Proteins) resistance than control mice, as well as more functionally active brown adipose tissue and increased energy expenditure.

  9. high levels of c-Jun (show JUN Proteins) enhance motility in part by driving the expression of ENPP2/Autotaxin

  10. Autotaxin generates lysophosphatidic acid from lysophophatidylcholine. The role of this pathway in T-lymphocyte homing, inflammation, and airway remodeling is studied and inhibitors are tested. Review.

Pig (Porcine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.

Cow (Bovine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.

ENPP2 Protein Profile

Protein Summary

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ENPP2

  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (enpp2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2)
  • ATX protein
  • ATX-X protein
  • AUTOTAXIN protein
  • LysoPLD protein
  • MGC132047 protein
  • NPP2 protein
  • Npps2 protein
  • PD-Ialpha protein
  • Pdnp2 protein
  • zgc:63550 protein

Protein level used designations for ENPP2

autotaxin , ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 , E-NPP 2 , autotaxin-t , extracellular lysophospholipase D , phosphodiesterase I/nucleotide pyrophosphatase 2 , plasma lysophospholipase D , lysoPLD , phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin) , atx

GENE ID SPECIES
100057101 Equus caballus
464353 Pan troglodytes
548690 Xenopus (Silurana) tropicalis
705287 Macaca mulatta
735240 Xenopus laevis
100173553 Pongo abelii
100219257 Taeniopygia guttata
5168 Homo sapiens
18606 Mus musculus
84050 Rattus norvegicus
393575 Danio rerio
420361 Gallus gallus
482026 Canis lupus familiaris
503658 Sus scrofa
532663 Bos taurus
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