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EGLN3 Proteins

(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.
EGLN3 Protein (AA 1-239) (His tag) EGLN3 Protein (AA 1-239) (His tag) EGLN3 Protein (AA 1-239) (His tag) (ABIN7122748)

EGLN3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB

EGLN3 Protein (AA 94-193) (GST tag) EGLN3 Protein (AA 94-193) (GST tag) EGLN3 Protein (AA 94-193) (GST tag) (ABIN1352451)

EGLN3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

EGLN3 Protein (AA 1-239) (GST tag) EGLN3 Protein (AA 1-239) (GST tag) EGLN3 Protein (AA 1-239) (GST tag) (ABIN1352449)

EGLN3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

EGLN3 Proteins by Grade

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EGLN3 Proteins by Origin

Find EGLN3 Proteins for a variety of species such as anti-Human EGLN3, anti-Mouse EGLN3. The species listed below are among those available. Click on a link to go to the corresponding products.

EGLN3 Proteins by Source

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EGLN3 Proteins by Protein Type

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EGLN3 Proteins by Application

Find EGLN3 Proteins validated for a specific application such as ELISA, WB, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular EGLN3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122748
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352451
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352449
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3092387
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136771
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5712938
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2720029
Quantity 20 μg
Datasheet Datasheet

Aliases for EGLN3 Proteins

egl-9 family hypoxia-inducible factor 3 (egln3) Proteins
egl-9 family hypoxia inducible factor 3 (EGLN3) Proteins
egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L) Proteins
egl-9 family hypoxia-inducible factor 3 (Egln3) Proteins
2610021G09Rik Proteins
AI505553 Proteins
AI648162 Proteins
EGLN3 Proteins
Hif-p4h-3 Proteins
HIFP4H3 Proteins
HIFPH3 Proteins
PHD-3 Proteins
phd3 Proteins
PHD3 Proteins
Phd3 Proteins
SM-20 Proteins
wu:fj78a08 Proteins
zgc:77019 Proteins
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