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Egl Nine Homolog 3 (C. Elegans) Proteins (EGLN3)

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Additionally we are shipping EGLN3 Antibodies (131) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat EGLN3 EGLN3 54702 Q62630
EGLN3 112407 Q91UZ4
EGLN3 112399 Q9H6Z9
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Top EGLN3 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 20 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EGLN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced EGLN3 Proteins

  1. Human EGLN3 Protein expressed in Escherichia coli (E. coli) - ABIN1098639 : Epstein, Gleadle, McNeill, Hewitson, ORourke, Mole, Mukherji, Metzen, Wilson, Dhanda, Tian, Masson, Hamilton, Jaakkola, Barstead, Hodgkin, Maxwell, Pugh, Schofield, Ratcliffe: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. in Cell 2001 (PubMed)
    Show all 2 references for ABIN1098639

More Proteins for Egl Nine Homolog 3 (C. Elegans) (EGLN3) Interaction Partners

Xenopus laevis Egl Nine Homolog 3 (C. Elegans) (EGLN3) interaction partners

  1. comparative analysis of phd1 (show EGLN2 Proteins), 2, and 3 expression in Xenopus laevis

Mouse (Murine) Egl Nine Homolog 3 (C. Elegans) (EGLN3) interaction partners

  1. PHD3 is an active participant in atherogenesis

  2. Cardiomyocyte-specific transgenic expression of PHD3 impairs the myocardial response to ischemia.

  3. PHD3 protects intestinal epithelial barrier function and reveal a hydroxylase-independent function of PHD3 in stabilizing occludin (show OCLN Proteins)

  4. depletion of PHD3 leads to increased stabilization of HIF-1alpha (show HIF1A Proteins) and inhibition of DNA damage response, both of which may contribute to the cardioprotective effect seen with depletion of PHD3.

  5. PHD3 loss sustains cell proliferation through the control of EGFR (show EGFR Proteins).

  6. combined deletion of Phd2 (show EGLN1 Proteins) and Phd3 dramatically decreased expression of phospholamban (PLN (show PLN Proteins)), resulted in sustained activation of calcium/calmodulin (show Calm2 Proteins)-activated kinase II (CaMKII (show CAMK2G Proteins)), and sensitized mice to chronic beta-adrenergic stress-induced myocardial injury

  7. PHD1 (show EGLN2 Proteins) and PHD3 deletions promote angiogenesis in ischemia-injured tissue by increasing HIF1-alpha (show HIF1A Proteins) stability.

  8. Using conditional PHD3-knockout mice, it was shown that PHD3 affects the production of Angptl2 (show ANGPTL2 Proteins) and additionally influences the response toward this apoptosis-modulating factor.

  9. ablation of the PHD3 gene resulted in increased angiogenesis and cardiac function after infarction thereby offering a potential target for management of ischemic myocardial disease

  10. PHD3 depletion did not affect the expression of the PDH (show PDP Proteins)-E1alpha, E1beta (show PDHB Proteins), and E2 subunits, or the phosphorylation status of E1alpha, but destabilized the PDH (show PDP Proteins) complex (PDC (show PDC Proteins)), resulting in less functional PDC (show PDC Proteins).

Human Egl Nine Homolog 3 (C. Elegans) (EGLN3) interaction partners

  1. In pancreatic Beta cells, knock-down of PHD3 inhibited glucose-stimulated insulin (show INS Proteins) secretion.

  2. Loss of PHD3 expression is associated with breast cancer.

  3. The selective efficacy of PZ was further demonstrated at the cellular level by observing inhibition of the PHD3-dependent DNA damage response pathway without stabilization of HIF-1alpha (show HIF1A Proteins).

  4. The enhanced expression of PHD3 might likely contribute to the poor neovascularization and affect the biological characterization in PDAC cancer cells

  5. The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 (show PAK2 Proteins) that occurs by attenuating p27S10 phosphorylation.

  6. PHD3 controls EGFR (show EGFR Proteins) activity by acting as a scaffolding protein that associates with the endocytic adaptor Eps15 (show EPS15 Proteins) and promotes the internalization of EGFR (show EGFR Proteins).

  7. PHD3 loss sustains cell proliferation through the control of EGFR (show EGFR Proteins).

  8. PHD3 SUMOylation occurs at a cluster of four lysines at the C-terminal end of the protein. Furthermore, PHD3 SUMOylation by SUMO2 or SUMO3 contributes to PHD3-mediated repression of HIF1-dependent transcriptional activity.

  9. HIFPH3 expression in human non-small cell lung cancer lesions is significantly higher than that in para-cancerous and normal lung tissues and is positively associated with lymph node metastasis and microvessel density.

  10. A novel role for PHD3 as a negative regulator of cell motility through posttranslational modification of nonmuscle actins.

EGLN3 Protein Profile

Protein Summary

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.

Gene names and symbols associated with EGLN3

  • egl nine homolog 3 (C. elegans) (egln3)
  • egl nine homolog 3 (egln3)
  • egl nine homolog 3 (LOC100354210)
  • egl nine homolog 3 (C. elegans) (EGLN3)
  • egl nine homolog 3 (C. elegans) (LOC100219039)
  • EGL nine homolog 3 (C. elegans) (Egln3)
  • egl-9 family hypoxia-inducible factor 3 (EGLN3)
  • 2610021G09Rik protein
  • AI505553 protein
  • AI648162 protein
  • EGLN3 protein
  • Hif-p4h-3 protein
  • HIFP4H3 protein
  • HIFPH3 protein
  • PHD-3 protein
  • Phd3 protein
  • SM-20 protein
  • wu:fj78a08 protein
  • zgc:77019 protein

Protein level used designations for EGLN3

Hif-p4h-3 , egl nine homolog 3 , phd3 , egl nine homolog 3 (C. elegans) , HIF-PH3 , HIF-prolyl hydroxylase 3 , HPH-3 , egl nine homolog 3, mitochondrial , factor-responsive smooth muscle protein , hypoxia-inducible factor prolyl hydroxylase 3 , prolyl hydroxylase domain-containing protein 3 , HIF prolyl hydroxylase 3 , HPH-1 , egl nine-like protein 3 isoform

GENE ID SPECIES
406602 Danio rerio
100145602 Xenopus (Silurana) tropicalis
100354210 Oryctolagus cuniculus
452850 Pan troglodytes
480286 Canis lupus familiaris
100219039 Taeniopygia guttata
100127282 Xenopus laevis
54702 Rattus norvegicus
423316 Gallus gallus
535578 Bos taurus
112407 Mus musculus
112399 Homo sapiens
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