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Elastase, Neutrophil Expressed Proteins (ELANE)

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Additionally we are shipping Elastase, Neutrophil Expressed Antibodies (146) and Elastase, Neutrophil Expressed Kits (91) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ELANE 1991 P08246
ELANE 50701 Q3UP87
Rat ELANE ELANE 299606  
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Top Elastase, Neutrophil Expressed Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$528.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   1 mg Log in to see 2 to 3 Days
$632.50
Details
HOST_Human Human Un-conjugated   200 μg Log in to see 5 to 6 Days
$770.00
Details
HOST_Human Human Un-conjugated 10 μg Log in to see 5 to 6 Days
$100.10
Details
Human Un-conjugated   0.5 mg Log in to see 2 to 3 Days
$144.57
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$715.97
Details
Human Un-conjugated   100 μg Log in to see 4 to 5 Days
$212.85
Details

ELANE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Top referenced Elastase, Neutrophil Expressed Proteins

  1. Human ELANE Protein expressed in Human - ABIN2544352 : Luyendyk, Shaw, Green, Maddox, Ganey, Roth: Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. in The Journal of pharmacology and experimental therapeutics 2005 (PubMed)

More Proteins for Elastase, Neutrophil Expressed (ELANE) Interaction Partners

Rhesus Monkey Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Results indicate targeting of a population of neutrophil elastase (NE) to the plasma membrane and internalization dependent on the C-terminal NE pro-peptide.

Human Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. An increased NE: A1 AT ratio is closely associated with liver Inflammation in patients with NASH (show SAMSN1 Proteins) and could serve as a novel marker to predict NASH (show SAMSN1 Proteins) in humans

  2. Neutrophil elastase activity is deleterious for airway epithelial cell homeostasis.

  3. insights into the PPE and HNE inhibition

  4. Different ELANE mutants show specific activation of different UPR pathways in congenital neutropenia.

  5. Neutrophil elastase was increased in the saliva (show RAG1AP1 Proteins) from COPD (show ARCN1 Proteins) patients and additionally distinguished smoking status.

  6. Paternal Somatic Mosaicism of a Novel Frameshift Mutation in ELANE Causing Severe Congenital Neutropenia.

  7. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  8. Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors.

  9. analysis of the mechanistic link between neutrophil elastase expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1beta (show IL1B Proteins) secretion from endothelial cells

  10. In patients with carotid plaques, both circulating and intraplaque polymorphonuclear neutrophils produce IL-8, VEGF and elastase, which are crucial for plaque development and progression.

Mouse (Murine) Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Serine protease (show F2 Proteins) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock

  2. Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration

  3. results of ultrasound studies using the elastase and AngII apoE (show APOE Proteins) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity

  4. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  5. SerpinA3N (show SERPINA3N Proteins) attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  6. Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  7. Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.

  8. In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions

  9. Lung cancer promotion by inflammation is partly mediated by activation of the IL-8 (show IL8 Proteins)/CXCR2 (show CXCR2 Proteins) pathway and subsequent recruitment of neutrophils and release of neutrophil elastase.

  10. a neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice

Elastase, Neutrophil Expressed (ELANE) Protein Profile

Protein Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Gene names and symbols associated with ELANE

  • proteinase 3 (prtn3)
  • elastase, neutrophil expressed (ELANE)
  • chymotrypsin-like elastase family, member 2A (CELA2A)
  • elastase, neutrophil expressed (Elane)
  • neutrophil elastase-like (LOC100522182)
  • Ela2 protein
  • ELANE protein
  • F430011M15Rik protein
  • GE protein
  • HLE protein
  • HNE protein
  • NE protein
  • PMN-E protein
  • SCN1 protein

Protein level used designations for ELANE

elastase 2, neutrophil , neutrophil elastase , elastase, neutrophil expressed , chymotrypsin-like elastase family member 2A , elastase-2 , elastase-2A , pancreatic elastase II , PMN elastase , bone marrow serine protease , granulocyte-derived elastase , human leukocyte elastase , leukocyte elastase , medullasin , polymorphonuclear elastase , serine protease

GENE ID SPECIES
448597 Xenopus (Silurana) tropicalis
721134 Macaca mulatta
749897 Pan troglodytes
100301482 Felis catus
397197 Sus scrofa
1991 Homo sapiens
50701 Mus musculus
299606 Rattus norvegicus
442980 Canis lupus familiaris
100724414 Cavia porcellus
100126050 Bos taurus
100522182 Sus scrofa
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