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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Additionally we are shipping Elastase, Neutrophil Expressed Kits (96) and Elastase, Neutrophil Expressed Proteins (14) and many more products for this protein.
Showing 10 out of 160 products:
Human Polyclonal ELANE Primary Antibody for EIA, WB - ABIN953688
Källquist, Rosén, Nordenfelt, Calafat, Janssen, Persson, Hansson, Olsson: Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. in Experimental cell research 2010
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Dog (Canine) Polyclonal ELANE Primary Antibody for FACS, IF (p) - ABIN1386058
Jeffery, Kimura, Gray, Lueth, Bellaire, LeVine: Dogs cast NETs too: Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia. in Veterinary immunology and immunopathology 2015
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Human Monoclonal ELANE Primary Antibody for EIA, Func - ABIN111823
Durant, Pederzoli, Lepelletier, Canteloup, Nusbaum, Lesavre, Witko-Sarsat: Apoptosis-induced proteinase 3 membrane expression is independent from degranulation. in Journal of leukocyte biology 2004
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Data suggest that neuropilin-1 (NRP1 (show NRP1 Antibodies)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (show TMEM37 Antibodies) (a peptide fragment of NE) in breast cancer cells.
This study proposes that acquisition of CSF3R (show CSF3R Antibodies) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (show SRI Antibodies) patients.
Faecal biomarkers lactoferrin (show LTF Antibodies), calprotectin (show S100A8 Antibodies), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.
In conclusion, site-specific CBG (show SERPINA6 Antibodies) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (show C6orf108 Antibodies) proteolysis by endogenous and exogenous elastases.
Although circulating nucleosomes and elastase - alpha 1-antitrypsin (show SERPINA1 Antibodies) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (show SLC44A2 Antibodies) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.
The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.
The results of the present study may indicate that NE activates the phosphoinositide-3 kinase/Akt (show AKT1 Antibodies) signaling pathway in leukemia cells to inhibit apoptosis and enhance cell proliferation
The HNE-TACE signalling pathway has an important role in the process of MUC5AC overexpression in chronic rhinosinusitis.
An increased NE: A1 AT ratio is closely associated with liver Inflammation in patients with NASH (show SAMSN1 Antibodies) and could serve as a novel marker to predict NASH (show SAMSN1 Antibodies) in humans
Neutrophil elastase activity is deleterious for airway epithelial cell homeostasis.
Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (show CEBPA Antibodies)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (show CEBPA Antibodies) are resistant to HFD-induced myelopoiesis.
Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).
Serine protease (show F2 Antibodies) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock
Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration
results of ultrasound studies using the elastase and AngII apoE (show APOE Antibodies) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity
Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.
SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.
Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.
In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
elastase 2, neutrophil
, neutrophil elastase
, elastase, neutrophil expressed
, chymotrypsin-like elastase family member 2A
, pancreatic elastase II
, PMN elastase
, bone marrow serine protease
, granulocyte-derived elastase
, human leukocyte elastase
, leukocyte elastase
, polymorphonuclear elastase
, serine protease