anti-Elastase, Neutrophil Expressed (ELANE) Antibodies

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Additionally we are shipping Elastase, Neutrophil Expressed Kits (106) and Elastase, Neutrophil Expressed Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ELANE 1991 P08246
ELANE 50701 Q3UP87
ELANE 299606  
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Top anti-Elastase, Neutrophil Expressed Antibodies at

Showing 10 out of 177 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Neutrophil elastase Antibody (N-term) (ABIN656021) western blot analysis in A2058 cell line lysates (35 µg/lane). This demonstrates the Neutrophil elastase antibody detected the Neutrophil elastase protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated EIA, WB Western blot analysis in A2058 cell line lysates (35ug/lane) using Neutrophil elastase  Antibody (N-term). This demonstrates this antibody detected the Neutrophil elastase protein (arrow). 0.4 mL Log in to see 6 to 8 Days
Dog Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Neutrophil Elastase/ELANE Polyclonal Antibody, Unconjugated (ABIN1386058) at 1:200 followed by conjugation to the secondary antibody and DAB staining. A549 cells probed with 	Neutrophil Elastase Polyclonal Antibody, Unconjugated  at 1:100 for 30 minutes followed by incubation with a conjugated secondary -PE) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange). 100 μL Log in to see 3 to 7 Days
Human Mouse Un-conjugated EIA, Func, FACS   0.2 mg Log in to see 6 to 8 Days
Mouse Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
Human Mouse Un-conjugated CyTOF, FACS, ICC, IHC, WB Detection of Neutrophil Elastase/ELA2 in THP-1 Human Cell Line by Flow Cytometry. THP-1 human acute monocytic leukemia cell line treated with 3 uM monensin for 3 hours was stained with Mouse Anti-Human Neutrophil Elastase/ELA2 Monoclonal Antibody. Detection of Human Neutrophil Elastase/ELA2 by Western Blot. Western blot shows lysates of human bone marrow and human lung tissue. PVDF membrane was probed with 0.1 ug/mL of Mouse Anti-Human Neutrophil Elastase/ELA2 Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
Human Rabbit Un-conjugated IHC (p) 1 mL Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA 200 μL Log in to see 7 to 9 Days
Dog Rabbit Alexa Fluor 555 FACS, IF (p)   100 μL Log in to see 14 to 21 Days

ELANE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Elastase, Neutrophil Expressed Antibodies

  1. Dog (Canine) Polyclonal ELANE Primary Antibody for FACS, IF (p) - ABIN1386058 : Jeffery, Kimura, Gray, Lueth, Bellaire, LeVine: Dogs cast NETs too: Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia. in Veterinary immunology and immunopathology 2015 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ELANE Primary Antibody for IA - ABIN2192191 : Dentener, Francot, Hiemstra, Tool, Verhoeven, Vandenabeele, Buurman: Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. in The Journal of infectious diseases 1997 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Elastase, Neutrophil Expressed Interaction Partners

Human Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Taken together, these observations support that the unusual HNE N-glycosylation, here reported for the first time, is involved in modulating multiple immune functions central to inflammation and infection.

  2. The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (show EIF2AK3 Antibodies) and CHOP (show DDIT3 Antibodies) is reported.

  3. results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (show ELN Antibodies) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy

  4. Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.

  5. Data suggest that neuropilin-1 (NRP1 (show NRP1 Antibodies)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (show TMEM37 Antibodies) (a peptide fragment of NE) in breast cancer cells.

  6. This study proposes that acquisition of CSF3R (show CSF3R Antibodies) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (show SRI Antibodies) patients.

  7. Faecal biomarkers lactoferrin (show LTF Antibodies), calprotectin (show S100A8 Antibodies), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.

  8. In conclusion, site-specific CBG (show SERPINA6 Antibodies) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (show C6orf108 Antibodies) proteolysis by endogenous and exogenous elastases.

  9. Although circulating nucleosomes and elastase - alpha 1-antitrypsin (show SERPINA1 Antibodies) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (show SLC44A2 Antibodies) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.

  10. The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.

Mouse (Murine) Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (show CEBPA Antibodies)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (show CEBPA Antibodies) are resistant to HFD-induced myelopoiesis.

  2. Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).

  3. Serine protease (show F2 Antibodies) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock

  4. Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration

  5. results of ultrasound studies using the elastase and AngII apoE (show APOE Antibodies) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity

  6. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  7. SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  8. Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  9. Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.

  10. In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions

Elastase, Neutrophil Expressed (ELANE) Antigen Profile

Protein Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Gene names and symbols associated with ELANE

  • proteinase 3 (prtn3) antibody
  • elastase, neutrophil expressed (ELANE) antibody
  • chymotrypsin-like elastase family, member 2A (CELA2A) antibody
  • elastase, neutrophil expressed (Elane) antibody
  • Ela2 antibody
  • ELANE antibody
  • F430011M15Rik antibody
  • GE antibody
  • HLE antibody
  • HNE antibody
  • NE antibody
  • PMN-E antibody
  • SCN1 antibody

Protein level used designations for ELANE

elastase 2, neutrophil , neutrophil elastase , elastase, neutrophil expressed , chymotrypsin-like elastase family member 2A , elastase-2 , elastase-2A , pancreatic elastase II , PMN elastase , bone marrow serine protease , granulocyte-derived elastase , human leukocyte elastase , leukocyte elastase , medullasin , polymorphonuclear elastase , serine protease

448597 Xenopus (Silurana) tropicalis
721134 Macaca mulatta
749897 Pan troglodytes
100301482 Felis catus
397197 Sus scrofa
1991 Homo sapiens
50701 Mus musculus
299606 Rattus norvegicus
442980 Canis lupus familiaris
100724414 Cavia porcellus
100126050 Bos taurus
100522182 Sus scrofa
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