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The longest protein isoform encoded by EFS contains an SH3 domain, which is known to be important in intracellular signal transduction. Additionally we are shipping Embryonal Fyn-Associated Substrate Antibodies (14) and Embryonal Fyn-Associated Substrate Proteins (5) and many more products for this protein.
EFS and CASS4 (show CASS4 ELISA Kits) protein function in the context of the larger CAS (show CSE1L ELISA Kits) family group. [Review]
we suggest that EFS should be considered as a novel tumor suppressor gene in prostate cancer.
Analysis of 16 Uveal melanoma showed full methylation of the EFS CpG island in 8 (50%), no methylation in 5(31%)and partial methylation in 3 (19%)tumors. Kaplan-Meier analysis revealed higher risk of metastatic progression for tumors with EFS methylation.
Sin-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production.
The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene.
Cas scaffolding protein family member 3
, signal transduction protein (SH3 containing)
, SRC-interacting protein
, signal-integrating protein