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Embryonic Ectoderm Development Proteins (EED)

EED encodes a member of the Polycomb-group (PcG) family. Additionally we are shipping Embryonic Ectoderm Development Antibodies (76) and Embryonic Ectoderm Development Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EED 8726 O75530
EED 13626 Q921E6
Rat EED EED 293104  
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Top Embryonic Ectoderm Development Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Sf-21 cells Human His tag 25 μg Log in to see 2 to 3 Days
$273.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,224.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,224.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,232.17
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,241.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

EED Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Top referenced Embryonic Ectoderm Development Proteins

  1. Human EED Protein expressed in Baculovirus infected Insect Cells - ABIN2004205 : Montgomery, Yee, Montgomery, Magnuson: Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation. in Journal of molecular biology 2007 (PubMed)

  2. Human EED Protein expressed in Wheat germ - ABIN1352339 : Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012 (PubMed)

More Proteins for Embryonic Ectoderm Development (EED) Interaction Partners

Human Embryonic Ectoderm Development (EED) interaction partners

  1. These results suggest that the SNPs of the EED gene might not be associated with susceptibility to CRC (show CALR Proteins).

  2. An integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 (show PRC1 Proteins) and 2, is reported.

  3. Data show that overall enhancer of zeste 2 (EZH2 (show EZH2 Proteins)), embryonic ectoderm development (EED) and suppressor of zeste 12 homolog (SUZ12 (show SUZ12 Proteins)) expression in the colorectal cancer (CRC (show CALR Proteins)) tissues was significantly increased than in the non-cancerous tissue.

  4. EED, a component of Polycomb (show CBX2 Proteins) repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (show HIST3H3 Proteins) (H3K27), was involved in epithelial-mesenchymal transition (EMT (show ITK Proteins)) of cancer cells induced by Transforming Growth Factor-beta (TGF-beta).

  5. Polycomb (show CBX2 Proteins) repressive complex 2 is recurrently inactivated through EED or SUZ12 (show SUZ12 Proteins) loss in malignant peripheral nerve sheath tumors.

  6. EZH2 (show EZH2 Proteins)-EED is necessary and sufficient for binding to the lncRNA HOTAIR.

  7. Although inactivating mutations in PRC2-encoding genes EZH2 (show EZH2 Proteins), EED, and SUZ12 (show SUZ12 Proteins) are present in T-cell acute lymphoblastic leukemia and in myeloid malignancies, gain-of-function mutations in EZH2 (show EZH2 Proteins) are frequently observed in B-cell lymphoma.

  8. EED mutants impair polycomb (show CBX2 Proteins) repressive complex 2 and is associated with myelodysplastic syndrome and related neoplasms

  9. Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis.

  10. Genetic defects in PRC2 components other than EZH2 (show EZH2 Proteins) are not common in myeloid malignancies.

Mouse (Murine) Embryonic Ectoderm Development (EED) interaction partners

  1. EED affects the lymphoid versus myeloid decision processes within the lymphomyeloid lineage

  2. Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.

  3. Data suggest that Eed (embryonic ectoderm development) is necessary to silence the pluripotency network during differentiation.

  4. An integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 (show PRC1 Proteins) and 2, is reported.

  5. a microRNA encoded by the imprinted Dlk1 (show DLK1 Proteins)-Dio3 (show DIO3 Proteins) region of mouse chromosome 12, miR (show MLXIP Proteins)-323-3p, targets Eed (embryonic ectoderm development) mRNA.

  6. Ectopic gain of EED along with depletion of KDM6B in preimplantation mouse embryos abrogates CDX2 (show CDX2 Proteins) and GATA3 (show GATA3 Proteins) gene expression in the nascent trophoectoderm lineage.

  7. It was shown that Ring1B (show RNF2 Proteins) interacted with multiple complexes in embryonic stem cells. Although H2A.Z (show H2AFZ Proteins) co-localized with Eed, Ring1B (show RNF2 Proteins) and CpG islands in chromatin, H2A.Z (show H2AFZ Proteins) still blanketed polycomb (show CBX2 Proteins) target loci in the absence of Suz12 (show SUZ12 Proteins), Eed, or Ring1B (show RNF2 Proteins).

  8. Data indicate that binding of EZH2 (show EZH2 Proteins), SUZ12 (show SUZ12 Proteins) and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.

  9. The role of polycomb (show CBX2 Proteins) repressive complex 2 (PRC2) function in leukemia development and progression, is reported.

  10. identify polycomb-like 2 (show MTF2 Proteins) and Polycomb (show CBX2 Proteins) Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb (show CBX2 Proteins) Repressive Complex 2 and polycomb-like 2 (show MTF2 Proteins)]

Embryonic Ectoderm Development (EED) Protein Profile

Protein Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with EED

  • embryonic ectoderm development (eed)
  • embryonic ectoderm development (EED)
  • embryonic ectoderm development (eed-b)
  • embryonic ectoderm development (Eed)
  • embryonic ectoderm development (LOC100344036)
  • embryonic ectoderm development (eed-a)
  • eed protein
  • ENSMUSG00000039373 protein
  • HEED protein
  • l(7)5Rn protein
  • l7Rn5 protein
  • lusk protein
  • psXEED protein
  • WAIT1 protein
  • Xeed protein
  • Xeed-A protein
  • Xeed-B protein
  • zgc:112509 protein

Protein level used designations for EED

polycomb protein eed , embryonic ectoderm development , WD protein associating with integrin cytoplasmic tails 1 , polycomb protein EED , embryonic ectoderm development protein variant 1 , polycomb protein eed-B , embryonic ectoderm development protein , lethal, Chr 7, Rinchik 5 , polycomb protein eed-A

GENE ID SPECIES
550079 Xenopus (Silurana) tropicalis
703866 Macaca mulatta
100601094 Nomascus leucogenys
8726 Homo sapiens
550463 Danio rerio
398420 Xenopus laevis
426381 Gallus gallus
404183 Bos taurus
13626 Mus musculus
293104 Rattus norvegicus
100344036 Oryctolagus cuniculus
100728793 Cavia porcellus
476779 Canis lupus familiaris
101113712 Ovis aries
734571 Xenopus laevis
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