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ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Additionally we are shipping Endoglin Antibodies (696) and Endoglin Proteins (52) and many more products for this protein.
Showing 8 out of 56 products:
The novel ENG c.-58G/A substitution in the Endoglin promoter co-segregates with Hereditary hemorrhagic telangiectasia symptoms in a family and appears to affect the transcriptional regulation of the gene, resulting in reduced Endoglin expression.
sEng treatment resulted in an activation of NF-kappaB (show NFKB1 ELISA Kits), IL-6 (show IL6 ELISA Kits), suggesting activation of pro-inflammatory phenotype in endothelial cells.
In adolescents with type 1 diabetes mellitus (T1DM), soluble endoglin concentrations might increase in parallel to the deterioration in endothelial function before subclinical structural vascular alterations.
Akt (show AKT1 ELISA Kits) level was reduced in preeclamptic placentas relative to preterm control. Inhibition of PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) resulted in significantly elevated soluble endoglin release from endothelial cells, had no effect on MMP14 (show MMP14 ELISA Kits) mRNA expression but resulted in significantly reduced TIMP3 (show TIMP3 ELISA Kits). In contrast inhibiting PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) in placental explants or primary trophoblast did not change soluble endoglin release.
the TGFbeta1 (show TGFB1 ELISA Kits) coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload
Increased ENG gene expression is associated with the Risk of Hepatocellular Carcinoma.
Study of four patients with pulmonary arterial hypertension associated with human immunodeficiency virus infection found predisposing mutations in the BMPR2 (show BMPR2 ELISA Kits), ACVRL1 (show ACVRL1 ELISA Kits) and ENG genes.
These results suggest that KLF6 (show KLF6 ELISA Kits) regulates MMP14 (show MMP14 ELISA Kits) transcription and is a critical player of the gene expression network triggered during endothelial repair.
In placenta, higher Eng immunoexpression was observed in both villi types of the preeclamptic compared to normotensive groups. Irrespective of pregnancy type (normotensive versus preeclampsia), there was no significant effect of HIV status on Eng immunoexpression within the exchange and conducting villi
Report marginal prognostic significance of endoglin expression in pancreatic ductal adenocarcinoma.
Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size.
Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction.
The changes in CD90 (show THY1 ELISA Kits) and CD105 expression in the testis and ovary of mice are reported.
the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients.
These results demonstrate a requirement for endoglin in descendants of Pax3 (show PAX3 ELISA Kits)-expressing vascular cell precursors.
The similarities in Eng-/- and Mlc2a-/- embryos suggest that Eng-/- mice may suffer from a primary heart developmental defect and secondary defects in vessel patterning.
results of our study provide evidence of endoglin as a valid target for cancer therapy and support further development of plasmid shRNA delivery, which have prolonged antitumor effect, especially in combined schedules
ENG deficiency leads to EC hyperpermeability through constitutive activation of RhoA (show RHOA ELISA Kits) and destabilization of endothelial barrier function.
endoglin is not localized with cell adhesion molecules involved in atherosclerosis, suggesting it might not participate in leukocyte accumulation in aorta of apoE (show APOE ELISA Kits)-deficient mice during atherogenesis
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endoglin (Osler-Rendu-Weber syndrome 1)
, CD105 antigen
, cell surface MJ7/18 antigen
, transmembrane glycoprotein