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ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Additionally we are shipping Endoglin Antibodies (711) and Endoglin Proteins (49) and many more products for this protein.
Showing 7 out of 58 products:
Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.
Soluble endoglin did not vary over the pregnancy course or between gestational hypertension, preeclampsia, and control groups.
Serum and placental LXR-alpha (show NR1H3 ELISA Kits) and endoglin levels were significantly higher in patients with preeclampsia than those in control group (P<0.05, each).
Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (show TGFB1 ELISA Kits)/Smad2 (show SMAD2 ELISA Kits) signaling pathway, but not Smad1 (show GARS ELISA Kits)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.
The novel ENG c.-58G/A substitution in the Endoglin promoter co-segregates with Hereditary hemorrhagic telangiectasia symptoms in a family and appears to affect the transcriptional regulation of the gene, resulting in reduced Endoglin expression.
sEng treatment resulted in an activation of NF-kappaB (show NFKB1 ELISA Kits), IL-6 (show IL6 ELISA Kits), suggesting activation of pro-inflammatory phenotype in endothelial cells.
In adolescents with type 1 diabetes mellitus (T1DM), soluble endoglin concentrations might increase in parallel to the deterioration in endothelial function before subclinical structural vascular alterations.
Akt (show AKT1 ELISA Kits) level was reduced in preeclamptic placentas relative to preterm control. Inhibition of PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) resulted in significantly elevated soluble endoglin release from endothelial cells, had no effect on MMP14 (show MMP14 ELISA Kits) mRNA expression but resulted in significantly reduced TIMP3 (show TIMP3 ELISA Kits). In contrast inhibiting PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) in placental explants or primary trophoblast did not change soluble endoglin release.
the TGFbeta1 (show TGFB1 ELISA Kits) coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload
Increased ENG gene expression is associated with the Risk of Hepatocellular Carcinoma.
Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size.
Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction.
The changes in CD90 (show THY1 ELISA Kits) and CD105 expression in the testis and ovary of mice are reported.
the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients.
These results demonstrate a requirement for endoglin in descendants of Pax3 (show PAX3 ELISA Kits)-expressing vascular cell precursors.
The similarities in Eng-/- and Mlc2a-/- embryos suggest that Eng-/- mice may suffer from a primary heart developmental defect and secondary defects in vessel patterning.
results of our study provide evidence of endoglin as a valid target for cancer therapy and support further development of plasmid shRNA delivery, which have prolonged antitumor effect, especially in combined schedules
ENG deficiency leads to EC hyperpermeability through constitutive activation of RhoA (show RHOA ELISA Kits) and destabilization of endothelial barrier function.
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endoglin (Osler-Rendu-Weber syndrome 1)
, CD105 antigen
, cell surface MJ7/18 antigen
, transmembrane glycoprotein