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EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001. Additionally we are shipping Endomucin Proteins (9) and Endomucin Kits (3) and many more products for this protein.
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Mouse (Murine) Monoclonal EMCN Primary Antibody for IHC (fro), IHC (p) - ABIN1107088
Kuhn, Brachtendorf, Kurth, Sonntag, Samulowitz, Metze, Vestweber: Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin. in The Journal of investigative dermatology 2002
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These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation.
A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis.
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001
, gastric cancer antigen Ga34
, mucin 14, endothelial