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Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) ELISA Kits

The protein encoded by ERAP1 is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. Additionally we are shipping ERAP1 Antibodies (60) and ERAP1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ERAP1 51752 Q9NZ08
ERAP1 80898 Q9EQH2
ERAP1 80897 Q9JJ22
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Top ERAP1 ELISA Kits at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.039 ng/ml 0.156-10 ng/mL 96 Tests Log in to see 11 to 13 Days
$910.56
Details
Mouse
96 Tests Log in to see 11 to 13 Days
$875.60
Details
Rat
96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for ERAP1 Interaction Partners

Human Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

  2. ERAP-1 has a significant influence on the B*51:01 peptidome and its affinity which provides a mechanism for the epistatic association of ERAP-1 and B*51:01 in Behcet's disease.

  3. KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking

  4. beta2i/MECL-1 (show PSMB10 ELISA Kits) and PA28 negatively affect C- and N-terminal cleavage and therefore epitope liberation from the proteasome, whereas ERAP1 destroys the MART-1 (show MLANA ELISA Kits)(26-35) epitope by overtrimming activity

  5. epistatic interaction between ERAP1 and the HLA class I alleles HLA-B*27 and HLA-B*40:01 affects susceptibility to ankylosing spondylitits

  6. The results reveal the nature of the functional interaction between A*29:02 and ERAP1 and suggest that this enzyme may affect the susceptibility to birdshot chorioretinopathy by altering the A*29:02 peptidome.

  7. ERAP1 downregulation is associated with loss of heterozygosity.

  8. Genetic variants and haplotypes of ERAP1 are associated with ankylosing spondylitis, psoriasis, and Behcet's disease in people of varying ancestries.

  9. CCR1, KLRC4 (show KLRC4 ELISA Kits), IL12A (show IL12A ELISA Kits)-AS1 (show PTGDR ELISA Kits), STAT4 (show STAT4 ELISA Kits), and ERAP1 are bona fide susceptibility genes for Behcet's disease.

  10. We concluded that ERAP1 variants are associated with AS in East Asian population, indicating a common pathogenic mechanism for AS in East Asians and Caucasians.

Mouse (Murine) Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. results suggest that several aminopeptidases play important roles in the maximum synthesis of NO in activated macrophages in a substrate peptide-dependent manner and ERAP1 is one of the aminopeptidases involved in the NO synthesis

  2. Data show that endoplasmic reticulum protein 44 (ERp44 (show ERP44 ELISA Kits)) forms a mixed disulfide bond with aminopeptidase (show ANPEP ELISA Kits) ERAP1 and controls the release of ERAP1 in a redox-dependent manner to control blood pressure.

  3. This study clarifies ERAP1's role in shaping immunodominance through creation and destruction of peptides in vivo and demonstrates the functional significance of ERAP1 in modulating T-cell killing based upon this role.

  4. These results suggest that secretion of ERAP1 is mediated by toll (show TLR4 ELISA Kits)-like receptors via induction of intermediate cytokines

  5. ERAP1 directly alters peptide binding and presentation by HLA-B27, thus demonstrating a potential pathogenic mechanism in ankylosing spondylitis.

  6. Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. ERAAP defined the characteristic amino termini of canonical MHC I peptides.

  7. MHC class Ib-restricted cytolytic effector cells specifically eliminated ERAAP-deficient cells in vitro and in vivo.

  8. endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma (show IFNG ELISA Kits)

  9. ERAAP silencing results in MHC-I peptide-loading defects eliciting rejection of the murine T-cell lymphoma RMA in syngeneic mice

  10. The characteristic peptide length, as well as composition, of class I histocompatibility peptide cargo is determined not only by the class-I peptide-binding groove, but also by ERAAP proteolysis in the endoplasmic reticulum.

ERAP1 Antigen Profile

Antigen Summary

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with ERAP1

  • endoplasmic reticulum aminopeptidase 1 (ERAP1) antibody
  • endoplasmic reticulum aminopeptidase 1 (erap1) antibody
  • zgc:56194 (zgc:56194) antibody
  • type 1 tumor necrosis factor receptor shedding aminopeptidase regulator (ARTS-1) antibody
  • type 1 tumor necrosis factor receptor shedding aminopeptidase regulator (LOC100352256) antibody
  • endoplasmic reticulum aminopeptidase 1 (Erap1) antibody
  • A-LAP antibody
  • ALAP antibody
  • Appils antibody
  • ARTS-1 antibody
  • Arts1 antibody
  • DKFZp469C044 antibody
  • ERAAP antibody
  • ERAAP1 antibody
  • MGC166160 antibody
  • PILS-AP antibody
  • PILSA antibody
  • PILSAP antibody

Protein level used designations for ERAP1

endoplasmic reticulum aminopeptidase 1 , endoplasmic reticulum aminopeptidase 1-like , type 1 tumor necrosis factor receptor shedding aminopeptidase regulator , adipocyte-derived leucine aminopeptidase , aminopeptidase PILS , aminopeptidase regulator of TNFR1 shedding , endoplasmic reticulum aminopeptidase associated with antigen processing , puromycin-insensitive leucyl-specific aminopeptidase , A-LAP , ARTS-1 , PILS-AP , VEGF-induced aminopeptidase , ER-aminopeptidase 1 , leucyl-specific aminopeptidase PILS

GENE ID SPECIES
427122 Gallus gallus
488898 Canis lupus familiaris
514617 Bos taurus
100010465 Monodelphis domestica
100173512 Pongo abelii
100391536 Callithrix jacchus
100477111 Ailuropoda melanoleuca
100496768 Xenopus (Silurana) tropicalis
100565356 Anolis carolinensis
100602026 Nomascus leucogenys
393175 Danio rerio
471835 Pan troglodytes
699996 Macaca mulatta
100352256 Oryctolagus cuniculus
51752 Homo sapiens
80898 Mus musculus
80897 Rattus norvegicus
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