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The protein encoded by ERN1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. Additionally we are shipping ERN1 Kits (38) and ERN1 Proteins (13) and many more products for this protein.
Showing 10 out of 156 products:
Human Polyclonal ERN1 Primary Antibody for EIA, IF - ABIN500048
Little, Ramakrishnan, Roy, Gazit, Lee: The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. in Critical reviews in eukaryotic gene expression 1995
Show all 4 references for ABIN500048
Human Polyclonal ERN1 Primary Antibody for EIA, IF - ABIN500050
Bertolotti, Zhang, Hendershot, Harding, Ron: Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. in Nature cell biology 2000
Show all 4 references for ABIN500050
Human Polyclonal ERN1 Primary Antibody for EIA, WB - ABIN500052
Shen, Chen, Hendershot, Prywes: ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. in Developmental cell 2002
Show all 4 references for ABIN500052
Human Monoclonal ERN1 Primary Antibody for IHC, WB - ABIN2869496
Shang, Lehrman: Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts. in Biochemical and biophysical research communications 2004
Show all 3 references for ABIN2869496
Human Monoclonal ERN1 Primary Antibody for IHC, ELISA - ABIN969116
Huang, Tan, Yoshida, Mori, Ma, Yen: Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. in Molecular and cellular biology 2005
Show all 3 references for ABIN969116
Dog (Canine) Polyclonal ERN1 Primary Antibody for WB - ABIN375027
Yokouchi, Hiramatsu, Hayakawa, Okamura, Du, Kasai, Takano, Shitamura, Shimada, Yao, Kitamura: Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. in The Journal of biological chemistry 2008
Human Polyclonal ERN1 Primary Antibody for IF (p), IHC (p) - ABIN1387531
Xu, Su, Song, Shi, Fu, Hu, Xia, Song, Song: Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release. in Chemical research in toxicology 2015
Human Polyclonal ERN1 Primary Antibody for IHC (fro), IF - ABIN318703
Zhang, Kaufman: Signaling the unfolded protein response from the endoplasmic reticulum. in The Journal of biological chemistry 2004
PKA-dependent IRE1alpha-XBP1 (show XBP1 Antibodies) activation is crucial for the transcriptional induction of Ucp1 (show UCP1 Antibodies) in brown adipocytes.
Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.
Data show that inositol requiring enzyme 1alpha (IRE1alpha), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Antibodies) proten-Hrd1 protein (show SYVN1 Antibodies) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Our results reveal a role for IRE1 in preventing a cell death-initializing step that emanates from the ER and provide a potential target for treating diseases characterized by ER stress, including diabetes and Wolfram syndrome.
Our data indicate that removal of XBP-1 (show XBP1 Antibodies) confers a kinetic delay in early stages of MCMV infection and suggest that the late targeting of IRE1 is aimed at inhibiting activities other than the splicing of XBP-1 (show XBP1 Antibodies) mRNA
SphK1 (show SPHK1 Antibodies) inhibited the IRE1alpha pathway by reducing IRE1alpha expression at the transcriptional level.
IRE1alpha may promote liver regeneration through acting as a signaling platform to regulate the STAT3 (show STAT3 Antibodies) pathway.
The present study thus reveals an intracellular pathway that integrates the UPR and osteoclast differentiation through activation of the IRE1alpha/XBP1 (show XBP1 Antibodies) pathway.
ER stress accentuated CVB3-induced myocardial inflammation through the IRE1-associated NF-kappaB (show NFKB1 Antibodies) pathway.
CReP (show PPP1R15B Antibodies) expression was markedly suppressed in XBP1 (show XBP1 Antibodies)-deficient mice livers due to hyperactivated Ire1alpha.
we used KO hepatocytes to demonstrate that PA-induced EV release was mediated by inositol requiring enzyme 1alpha (IRE1alpha)/X-box binding protein-1 (show XBP1 Antibodies)
Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism
Overexpression of IRE1 is associated with breast cancer.
Data indicate that site-directed mutagenesis of inositol requiring enzyme 1 alpha (IRE1alpha) altered the enzymatic activities.
Brucella abortus infection induces AMPK (show PRKAA1 Antibodies) activation in HeLa cells and this activation is dependent on the RNase activity of inositol-requiring enzyme 1 (IRE1).
IRE1 inhibition affects the expression of insulin (show INS Antibodies)-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells.
Our results reveal that IRE1alpha-XBP1 (show XBP1 Antibodies) pathway plays an important role in tumor progression and epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)), and IRE1alpha could be employed as a novel prognostic marker and a promising therapeutic target for CRC (show CALR Antibodies).
Data indicated that the relative timing of IRE1 and PERK signalling determines the shift from cell survival to apoptosis.
Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
endoplasmic reticulum-to-nucleus signaling 1
, inositol-requiring 1 alpha
, inositol-requiring protein 1
, serine/threonine-protein kinase/endoribonuclease IRE1
, endoplasmic reticulum-to-nucleus signaling 2
, inositol-requiring 1 (Yeast homologue)
, inositol-requiring 1 beta
, inositol-requiring protein 2
, serine/threonine-protein kinase/endoribonuclease IRE2
, ER to nucleus signalling 1
, inositol-requiring 1
, inositol-requiring enzyme 1
, protein kinase/endoribonuclease
, endoplasmic reticulum (ER) to nucleus signalling 1
, endoplasmic reticulum to nucleus signalling 1