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Endoplasmic Reticulum To Nucleus Signaling 1 Proteins (ERN1)

The protein encoded by ERN1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. Additionally we are shipping ERN1 Antibodies (156) and ERN1 Kits (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ERN1 78943 Q9EQY0
ERN1 2081 O75460
ERN1 498013  
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Top ERN1 Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ERN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , , ,
, , ,
Rat (Rattus)

Top referenced ERN1 Proteins

  1. Human ERN1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004877 : Trentmann: ERN1, a novel ethylene-regulated nuclear protein of Arabidopsis. in Plant molecular biology 2000 (PubMed)
    Show all 5 references for ABIN2004877

More Proteins for Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) Interaction Partners

Mouse (Murine) Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

  1. PKA-dependent IRE1alpha-XBP1 (show XBP1 Proteins) activation is crucial for the transcriptional induction of Ucp1 (show UCP1 Proteins) in brown adipocytes.

  2. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  3. Data show that inositol requiring enzyme 1alpha (IRE1alpha), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Proteins) proten-Hrd1 protein (show SYVN1 Proteins) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  4. Our results reveal a role for IRE1 in preventing a cell death-initializing step that emanates from the ER and provide a potential target for treating diseases characterized by ER stress, including diabetes and Wolfram syndrome.

  5. Our data indicate that removal of XBP-1 (show XBP1 Proteins) confers a kinetic delay in early stages of MCMV infection and suggest that the late targeting of IRE1 is aimed at inhibiting activities other than the splicing of XBP-1 (show XBP1 Proteins) mRNA

  6. SphK1 (show SPHK1 Proteins) inhibited the IRE1alpha pathway by reducing IRE1alpha expression at the transcriptional level.

  7. IRE1alpha may promote liver regeneration through acting as a signaling platform to regulate the STAT3 (show STAT3 Proteins) pathway.

  8. The present study thus reveals an intracellular pathway that integrates the UPR and osteoclast differentiation through activation of the IRE1alpha/XBP1 (show XBP1 Proteins) pathway.

  9. ER stress accentuated CVB3-induced myocardial inflammation through the IRE1-associated NF-kappaB (show NFKB1 Proteins) pathway.

  10. CReP (show PPP1R15B Proteins) expression was markedly suppressed in XBP1 (show XBP1 Proteins)-deficient mice livers due to hyperactivated Ire1alpha.

Human Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

  1. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  2. Overexpression of IRE1 is associated with breast cancer.

  3. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  4. Data indicate that site-directed mutagenesis of inositol requiring enzyme 1 alpha (IRE1alpha) altered the enzymatic activities.

  5. Brucella abortus infection induces AMPK (show PRKAA1 Proteins) activation in HeLa cells and this activation is dependent on the RNase activity of inositol-requiring enzyme 1 (IRE1).

  6. IRE1 inhibition affects the expression of insulin (show INS Proteins)-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells.

  7. Our results reveal that IRE1alpha-XBP1 (show XBP1 Proteins) pathway plays an important role in tumor progression and epithelial-to-mesenchymal transition (EMT (show ITK Proteins)), and IRE1alpha could be employed as a novel prognostic marker and a promising therapeutic target for CRC (show CALR Proteins).

  8. Data indicated that the relative timing of IRE1 and PERK signalling determines the shift from cell survival to apoptosis.

  9. Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status

  10. the present study provides initial evidence that RITA (show ZNF331 Proteins) upregulates the expression level of IRE1a by increasing the stability of IRE1alpha mRNA in irradiated mtp53-expressing cervical cancer cells

ERN1 Protein Profile

Protein Summary

The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.

Gene names and symbols associated with ERN1

  • endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1)
  • endoplasmic reticulum (ER) to nucleus signalling 2 (Ern2)
  • endoplasmic reticulum to nucleus signaling 1 (ERN1)
  • endoplasmic reticulum to nucleus signaling 1 (Ern1)
  • endoplasmic reticulum to nucleus signalling 1 (LOC100357346)
  • 9030414B18Rik protein
  • AI225830 protein
  • C85377 protein
  • Ern1 protein
  • hIRE1p protein
  • IRE1 protein
  • IRE1a protein
  • Ire1alpha protein
  • Ire1b protein
  • IRE1P protein
  • RGD1559716 protein

Protein level used designations for ERN1

endoplasmic reticulum-to-nucleus signaling 1 , inositol-requiring 1 alpha , inositol-requiring protein 1 , ire1-alpha , serine/threonine-protein kinase/endoribonuclease IRE1 , endoplasmic reticulum-to-nucleus signaling 2 , inositol-requiring 1 (Yeast homologue) , inositol-requiring 1 beta , inositol-requiring protein 2 , ire1-beta , mIre1 , serine/threonine-protein kinase/endoribonuclease IRE2 , ER to nucleus signalling 1 , inositol-requiring 1 , inositol-requiring enzyme 1 , protein kinase/endoribonuclease , endoplasmic reticulum (ER) to nucleus signalling 1 , endoplasmic reticulum to nucleus signalling 1

GENE ID SPECIES
78943 Mus musculus
26918 Mus musculus
2081 Homo sapiens
498013 Rattus norvegicus
100733391 Cavia porcellus
100510978 Sus scrofa
610766 Canis lupus familiaris
524719 Bos taurus
771230 Gallus gallus
101102746 Ovis aries
100357346 Oryctolagus cuniculus
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