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anti-Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) Antibodies

The protein encoded by ERN1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. Additionally we are shipping ERN1 Kits (32) and ERN1 Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ERN1 78943 Q9EQY0
ERN1 2081 O75460
ERN1 498013  
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Top anti-ERN1 Antibodies at antibodies-online.com

Showing 10 out of 158 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN308413 (0.03µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of IRE1p in A-20 cells with AP30444PU-N IRE1p antibody at 1 μg/ml. Immunofluorescence of IRE1p in A20 cells with AP30444PU-N IRE1p antibody at 2 ug/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (fro), IF, WB 50 μg Log in to see 6 to 8 Days
$308.00
Details
Human Mouse Un-conjugated IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human Placenta tissues using ERN1 mouse mAb Figure 2: Immunohistochemical analysis of paraffin-embedded human brain tissue (A) and stomach tissue (B), showing cytoplasmic localization using ERN1 mouse mAb with DAB staining. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of IRE1p in A20 cells with AP30445PU-N IRE1p antibody at 1 μg/ml. Western blot analysis of IRE1p in A-20 cell lysate with AP30445PU-N IRE1p antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of IRE1p in Raji cell lysate with AP30446PU-N IRE1p antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 100 μL Log in to see 3 to 7 Days
$317.90
Details
Human Mouse Un-conjugated ELISA, IHC, WB   100 μL Log in to see 10 to 11 Days
$464.29
Details
Mouse Rabbit Un-conjugated WB Mouse Ern1 Antibody (C-term) (ABIN658171) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the Ern1 antibody detected the Ern1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

ERN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ERN1 Antibodies

  1. Human Polyclonal ERN1 Primary Antibody for EIA, IF - ABIN500048 : Little, Ramakrishnan, Roy, Gazit, Lee: The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. in Critical reviews in eukaryotic gene expression 1995 (PubMed)
    Show all 4 references for ABIN500048

  2. Human Polyclonal ERN1 Primary Antibody for EIA, IF - ABIN500050 : Bertolotti, Zhang, Hendershot, Harding, Ron: Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. in Nature cell biology 2000 (PubMed)
    Show all 4 references for ABIN500050

  3. Human Polyclonal ERN1 Primary Antibody for EIA, WB - ABIN500052 : Shen, Chen, Hendershot, Prywes: ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. in Developmental cell 2002 (PubMed)
    Show all 4 references for ABIN500052

  4. Human Monoclonal ERN1 Primary Antibody for ELISA, IHC - ABIN2869496 : Shang, Lehrman: Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 3 references for ABIN2869496

  5. Human Monoclonal ERN1 Primary Antibody for IHC, ELISA - ABIN969116 : Huang, Tan, Yoshida, Mori, Ma, Yen: Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. in Molecular and cellular biology 2005 (PubMed)
    Show all 3 references for ABIN969116

  6. Human Polyclonal ERN1 Primary Antibody for IF (p), IHC (p) - ABIN1387531 : Xu, Su, Song, Shi, Fu, Hu, Xia, Song, Song: Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release. in Chemical research in toxicology 2015 (PubMed)
    Show all 2 references for ABIN1387531

  7. Dog (Canine) Polyclonal ERN1 Primary Antibody for WB - ABIN375027 : Yokouchi, Hiramatsu, Hayakawa, Okamura, Du, Kasai, Takano, Shitamura, Shimada, Yao, Kitamura: Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. in The Journal of biological chemistry 2008 (PubMed)

  8. Human Polyclonal ERN1 Primary Antibody for IHC (fro), IF - ABIN318703 : Zhang, Kaufman: Signaling the unfolded protein response from the endoplasmic reticulum. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against ERN1 Interaction Partners

Mouse (Murine) Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

  1. this study shows that IRE1alpha is a critical switch governing M1-M2 macrophage polarization and energy balance in obesity

  2. Findings indicate that PERK (show EIF2AK3 Antibodies) kinase-activating transcription factor 4 (ATF4 (show ATF4 Antibodies)) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 Antibodies)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha) expression.

  3. Palmitate increased TRB3 (show TRIB3 Antibodies) expression, activated IRE1alpha signaling, and reduced the insulin (show INS Antibodies)-dependent Akt (show AKT1 Antibodies) phosphorylation. Knocking down TRB3 (show TRIB3 Antibodies) or IRE1alpha did not prevent the inhibitory effect of palmitate on Akt (show AKT1 Antibodies) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.

  4. Data show that EIF2AK3/PERK (show EIF2AK3 Antibodies)-mediated downregulation of miR (show MLXIP Antibodies)-424(322)-503 cluster regulates optimal activation of IRE1 protein and activating transcription factor 6 (ATF6 (show ATF6 Antibodies)) during conditions of endoplasmic reticulum stress.

  5. PKA-dependent IRE1alpha-XBP1 (show XBP1 Antibodies) activation is crucial for the transcriptional induction of Ucp1 (show UCP1 Antibodies) in brown adipocytes.

  6. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  7. Data show that inositol requiring enzyme 1alpha (IRE1alpha), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Antibodies) proten-Hrd1 protein (show SYVN1 Antibodies) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  8. Our results reveal a role for IRE1 in preventing a cell death-initializing step that emanates from the ER and provide a potential target for treating diseases characterized by ER stress, including diabetes and Wolfram syndrome.

  9. Our data indicate that removal of XBP-1 (show XBP1 Antibodies) confers a kinetic delay in early stages of MCMV infection and suggest that the late targeting of IRE1 is aimed at inhibiting activities other than the splicing of XBP-1 (show XBP1 Antibodies) mRNA

  10. SphK1 (show SPHK1 Antibodies) inhibited the IRE1alpha pathway by reducing IRE1alpha expression at the transcriptional level.

Human Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

  1. Crucially, Chlamydia trachomatis infection resulted in robust IRE1alpha RNAse activity that was dependent on TLR4 (show TLR4 Antibodies) signalling and inhibition of IRE1alpha RNAse activity prevented PKR (show PKLR Antibodies) activation.

  2. Pretreatment by IRE1 agonist tunicamycin or JNK (show MAPK8 Antibodies) agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1-ASK1 (show MAP3K5 Antibodies)-JNK (show MAPK8 Antibodies) pathway

  3. Results indicate that excessive activation of the endoplasmic reticulum stress-associated IRE1alpha pathway is involved in LC neuronal apoptosis induced by single prolonged stress exposure; this may be a crucial mechanism of the pathogenesis of post- traumatic stress disorder

  4. these results confirmed that ER stress-mediated apoptosis contributes to the protection effects of naringenin against H/R injury, which is potentially involved in ATF6, IRE1alpha and PERK signaling activation.

  5. Structural and mechanistic studies of IRE1

  6. Inhibition of IRE1 signaling enzyme function affects the expression of NR3C1 (show NR3C1 Antibodies) and related genes in U87 glioma cells in gene specific manner and all these genes are regulated by hypoxia preferentially through IRE1 signaling pathway of the endoplasmic reticulum stress.

  7. Data suggest that ubiquitin D (UBD (show UBD Antibodies)) provides a negative feedback on cytokine-induced activation of the endoplasmic reticulum to nucleus signaling 1 (IRE1alpha)/c-Jun N-terminal kinase (JNK) pro-apoptotic pathway in cytokine-exposed beta cells.

  8. we used KO hepatocytes to demonstrate that PA-induced EV release was mediated by inositol requiring enzyme 1alpha (IRE1alpha)/X-box binding protein-1 (show XBP1 Antibodies)

  9. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  10. Overexpression of IRE1 is associated with breast cancer.

ERN1 Antigen Profile

Protein Summary

The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.

Gene names and symbols associated with ERN1

  • endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1) antibody
  • endoplasmic reticulum (ER) to nucleus signalling 2 (Ern2) antibody
  • endoplasmic reticulum to nucleus signaling 1 (ERN1) antibody
  • endoplasmic reticulum to nucleus signaling 1 (Ern1) antibody
  • endoplasmic reticulum to nucleus signalling 1 (LOC100357346) antibody
  • 9030414B18Rik antibody
  • AI225830 antibody
  • C85377 antibody
  • Ern1 antibody
  • hIRE1p antibody
  • IRE1 antibody
  • IRE1a antibody
  • Ire1alpha antibody
  • Ire1b antibody
  • IRE1P antibody
  • RGD1559716 antibody

Protein level used designations for ERN1

endoplasmic reticulum-to-nucleus signaling 1 , inositol-requiring 1 alpha , inositol-requiring protein 1 , ire1-alpha , serine/threonine-protein kinase/endoribonuclease IRE1 , endoplasmic reticulum-to-nucleus signaling 2 , inositol-requiring 1 (Yeast homologue) , inositol-requiring 1 beta , inositol-requiring protein 2 , ire1-beta , mIre1 , serine/threonine-protein kinase/endoribonuclease IRE2 , ER to nucleus signalling 1 , inositol-requiring 1 , inositol-requiring enzyme 1 , protein kinase/endoribonuclease , endoplasmic reticulum (ER) to nucleus signalling 1 , endoplasmic reticulum to nucleus signalling 1

GENE ID SPECIES
78943 Mus musculus
26918 Mus musculus
2081 Homo sapiens
498013 Rattus norvegicus
100733391 Cavia porcellus
100510978 Sus scrofa
610766 Canis lupus familiaris
524719 Bos taurus
771230 Gallus gallus
101102746 Ovis aries
100357346 Oryctolagus cuniculus
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